Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 1/20 | 0.79 |
| ▸ | NT5E | P21589 | 1/20 | 0.74 |
| ▸ | KRAS | P01116 | 6/20 | 0.74 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.73 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.69 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.67 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.67 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.67 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.63 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.63 |
| ▸ | P2RY1 | P47900 | 3/20 | 0.62 |
| ▸ | SRC | P12931 | 1/20 | 0.62 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.62 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.62 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL407395 | 0.96 | NT5E (0.77) | TGM2NT5EKRASFUT5P2RX3 | |
| SCHEMBL21067722 | 0.96 | TGM2 (0.85) | TGM2NT5EKRASFUT5P2RX3 | |
| SCHEMBL29429843 | 0.96 | TGM2 (0.85) | TGM2NT5EKRASFUT5P2RX3 | |
| SCHEMBL851357 | 0.96 | TGM2 (0.85) | TGM2NT5EKRASFUT5P2RX3 | |
| SCHEMBL18769114 | 0.96 | TGM2 (0.85) | TGM2NT5EKRASFUT5P2RX3 | |
| SCHEMBL3437211 | 0.93 | TGM2 (0.79) | TGM2NT5EKRASFUT5P2RX3 | |
| SCHEMBL32661169 | 0.93 | TGM2 (0.79) | TGM2NT5EKRASFUT5P2RX3 | |
| SCHEMBL1304258 | 0.93 | TGM2 (0.81) | TGM2NT5EKRASFUT5P2RX3 | |
| SCHEMBL376140 | 0.93 | TGM2 (0.81) | TGM2NT5EKRASFUT5P2RX3 | |
| Gtp SCHEMBL5809658 | 0.93 | TGM2 (0.81) | TGM2NT5EKRASFUT5P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7807653-B2 | Nucleotide mimics and their prodrugs | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2010-10-05 | — | — | US | disclosed |
| US-7598230-B2 | For the treatment of viral infections, microbial infections, and proliferative disorders; contain di- or triphosphate moeity mimetics, such as those containing boron anions | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2009-10-06 | — | — | US | disclosed |
| US-20070265224-A1 | Nucleotide mimics and their prodrugs | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2007-11-15 | — | — | US | disclosed |
| US-20070259832-A1 | Nucleotide mimics and their prodrugs | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2007-11-08 | — | — | US | disclosed |
| US-7285658-B2 | Nucleotide mimics and their prodrugs | BIOTA, INC. (US) | 2007-10-23 | — | — | US | disclosed |
| EP-1485395-A2 | NUCLEOTIDE MIMICS AND THEIR PRODRUGS | Biota, Inc. (US) | 2004-12-15 | — | — | EP | disclosed |
| WO-2003072757-A9 | NUCLEOTIDE MIMICS AND THEIR PRODRUGS | BIOTA INC (US) | 2004-10-21 | — | — | WO | disclosed |
| US-20040059104-A1 | Nucleotide mimics and their prodrugs | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2004-03-25 | — | — | US | disclosed |
| WO-2003072757-A2 | NUCLEOTIDE MIMICS AND THEIR PRODRUGS | BIOTA, INC. (US) | 2003-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259832-A1 | Nucleotide mimics and their prodrugs | NUDT14, ENTPD5, MTAP | TGM2 4048/4885NT5E 39/4885KRAS 365/4885 |
| US-20070265224-A1 | Nucleotide mimics and their prodrugs | NUDT14, ENTPD5, MTAP | TGM2 4048/4885NT5E 39/4885KRAS 365/4885 |
| US-20040059104-A1 | Nucleotide mimics and their prodrugs | NUDT14, ENTPD5, MTAP | TGM2 4048/4885NT5E 39/4885KRAS 365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.