Gtp

Gtp

SCHEMBL5809658

Nc1nc2c(ncn2[C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@@H]2O)c(=O)[nH]1

nearest known ligand 0.81

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TGM2 P21980 1/20 0.81
NT5E P21589 1/20 0.76
KRAS P01116 2/20 0.76
FUT5 Q11128 1/20 0.75
P2RX3 P56373 2/20 0.71
P2RY6 Q15077 2/20 0.71
P2RY2 P41231 1/20 0.71
P2RY4 P51582 1/20 0.71
P2RY1 P47900 4/20 0.68
ENPP1 P22413 2/20 0.68
P2RX1 P51575 1/20 0.68
P2RY11 Q96G91 1/20 0.68
P2RX4 Q99571 1/20 0.68
P2RY12 Q9H244 1/20 0.66
IMPDH2 P12268 5/20 0.65
IMPDH1 P20839 1/20 0.65
DCPS Q96C86 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Gtp SCHEMBL18271799 1.00 TGM2 (0.81) TGM2NT5EKRASFUT5P2RX3
Gtp SCHEMBL3333959 1.00 TGM2 (0.81) TGM2NT5EKRASFUT5P2RX3
SCHEMBL376140 1.00 TGM2 (0.81) TGM2NT5EKRASFUT5P2RX3
Gtp SCHEMBL18784960 1.00 TGM2 (0.81) TGM2NT5EKRASFUT5P2RX3
SCHEMBL376139 1.00 TGM2 (0.81) TGM2NT5EKRASFUT5P2RX3
SCHEMBL1304258 1.00 TGM2 (0.81) TGM2NT5EKRASFUT5P2RX3
SCHEMBL19691775 1.00 TGM2 (0.81) TGM2NT5EKRASFUT5P2RX3
SCHEMBL2593095 1.00 TGM2 (0.81) TGM2NT5EKRASFUT5P2RX3
Gtp SCHEMBL17367368 1.00 TGM2 (0.81) TGM2NT5EKRASFUT5P2RX3
Gtp SCHEMBL96708 1.00 TGM2 (0.81) TGM2NT5EKRASFUT5P2RX3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240309447-A1 METHODS AND KITS FOR PREPARING A SAMPLE COMPRISING ONE OR MORE RNA MOLECULES FOR SEQUENCING THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2024-09-19 US claimed
US-20040127435-A1 Uses for inhibitors of inosine monophosphate dehydrogenase REGENTS OF THE UNIVERSITY OF CALIFORNIA 2004-07-01 US claimed
CN-121041304-B Application of CCT018159 and nelarabine in preparation of acute leukemia drugs HARBIN MEDICAL UNIVERSITY (CN) 2026-05-29 CN disclosed
CN-121041304-A Application of CCT018159 and nelarabine in preparation of acute leukemia drugs 哈尔滨医科大学 2025-12-02 CN disclosed
US-20240309447-A1 METHODS AND KITS FOR PREPARING A SAMPLE COMPRISING ONE OR MORE RNA MOLECULES FOR SEQUENCING THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2024-09-19 US disclosed
WO-2006114065-A2 USE OF COMPOUNDS TO INHIBIT NEOPLASIA INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY A CADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 2006-11-02 WO disclosed
US-20040127435-A1 Uses for inhibitors of inosine monophosphate dehydrogenase REGENTS OF THE UNIVERSITY OF CALIFORNIA 2004-07-01 US disclosed
US-20040096436-A1 Method for treating cancer comprising administering to a subject in need of such treatment a therapeutically effective amount of a member selected from an inhibitor of a protein kinase, an enantiomer of such a compound, a prodrug of such a REGENTS OF THE UNIVERSITY OF CALIFORNIA 2004-05-20 US disclosed
WO-2004012769-A1 THERAPEUTIC INHIBITIONOF PROTEIN KINASES IN CANCER CELLS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2004-02-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040096436-A1 Method for treating cancer comprising administering to a subject in need of such treatment a therapeutically effective amount of a member selected from an inhibitor of a protein kinase, an enantiomer of such a compound, a prodrug of such a IMPDH1, IMPDH2, DCK TGM2 1994/4885NT5E 576/4885KRAS 1035/4885
US-20040127435-A1 Uses for inhibitors of inosine monophosphate dehydrogenase IMPDH1, IMPDH2, IMPA1 TGM2 880/4885NT5E 57/4885KRAS 854/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.