Flavanone

Flavanone

SCHEMBL3438656

O=C1CC(c2ccccc2)Oc2ccccc21.O=C1c2c(ccc(O)c2O)OC(O)(c2ccccc2)C1(O)O

nearest known ligand 0.53

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 5/20 0.53
ADORA3 P0DMS8 3/20 0.53
AR P10275 3/20 0.53
CYP19A1 P11511 3/20 0.53
HSD17B10 Q99714 2/20 0.53
KDM4E B2RXH2 1/20 0.53
MAPT P10636 3/20 0.51
NPC1 O15118 3/20 0.51
RAB9A P51151 3/20 0.51
CYP3A4 P08684 2/20 0.51
MAPK1 P28482 1/20 0.51
AXL P30530 1/20 0.51
CYP1A1 P04798 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP1B1 Q16678 1/20 0.46
PLK1 P53350 1/20 0.46
MEN1 O00255 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1068646 0.82 KDM4E (0.35) MAOBADORA3HSD17B10KDM4EMAPT
SCHEMBL30658588 0.82 KDM4E (0.35) MAOBADORA3HSD17B10KDM4EMAPT
Flavanone SCHEMBL3438655 0.80 MAOB (0.55) MAOBADORA3ARCYP19A1HSD17B10
Flavanone SCHEMBL12660199 0.73 MAOB (1.00) MAOBADORA3ARCYP19A1HSD17B10
Flavanone SCHEMBL29843289 0.73 MAOB (1.00) MAOBADORA3ARCYP19A1HSD17B10
Flavanone SCHEMBL29470801 0.73 MAOB (1.00) MAOBADORA3ARCYP19A1HSD17B10
Flavanone SCHEMBL19745 0.73 MAOB (1.00) MAOBADORA3ARCYP19A1HSD17B10
Flavanone SCHEMBL12189591 0.73 MAOB (1.00) MAOBADORA3ARCYP19A1HSD17B10
Flavanone SCHEMBL27595693 0.72 ADORA3 (0.88) MAOBADORA3ARCYP19A1HSD17B10
Flavanone SCHEMBL27610362 0.72 MAOB (0.90) MAOBADORA3ARCYP19A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2484773-A2 Process for producing anthocyanins The Research Foundation of State University of New York (US) 2012-08-08 EP disclosed
US-7807422-B2 set of genes which encodes for enzymes which can convert substrates belonging to the general category of phenylpropanoids and result in the production of flavanones; without the need for chemical conversion THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 2010-10-05 US disclosed
US-20090239272-A1 set of genes which encodes for enzymes which can convert substrates belonging to the general category of phenylpropanoids and result in the production of flavanones; without the need for chemical conversion KOFFAS MATTHEOS 2009-09-24 US disclosed
US-7338791-B2 Introducing the set of genes into a heterologous host cell, allowing growth of the cells in a suitable medium such that the expression of the genes results in production of enzymes; culturing the cell under conditions permitting the synthesis of the flavonoid by the cells; isolating s flavonoids THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 2008-03-04 US disclosed
EP-1778850-A2 PRODUCTION OF FLAVONOIDS BY RECOMBINANT MICROORGANISMS THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 2007-05-02 EP disclosed
US-20060084135-A1 Compositions for manipulating the lifespan and stress response of cells and organisms BIOMOL INTERNATIONAL, INC. 2006-04-20 US disclosed
US-20060019334-A1 Introducing the set of genes into a heterologous host cell, allowing growth of the cells in a suitable medium such that the expression of the genes results in production of enzymes; culturing the cell under conditions permitting the synthesis of the flavonoid by the cells; isolating s flavonoids NATIONAL SCIENCE FOUNDATION 2006-01-26 US disclosed
WO-2006010117-A2 PRODUCTION OF FLAVONOIDS BY RECOMBINANT MICROORGANISMS THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 2006-01-26 WO disclosed