Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15139607 | 0.83 | POLB (0.71) | POLBMAPTFKBP1AALDH1A1GLA | |
| SCHEMBL3973348 | 0.80 | POLB (0.71) | POLBFKBP1AALDH1A1GLAKMT2A | |
| SCHEMBL3369957 | 0.80 | POLB (0.67) | POLBFKBP1AALDH1A1GLAKMT2A | |
| SCHEMBL6613032 | 0.80 | POLB (0.71) | POLBMAPTFKBP1AALDH1A1GLA | |
| SCHEMBL1853129 | 0.79 | POLB (0.71) | POLBLMNAFKBP1AALDH1A1GLA | |
| SCHEMBL10048553 | 0.79 | POLB (0.66) | POLBLMNAMAPTFKBP1AALDH1A1 | |
| SCHEMBL12169381 | 0.76 | LMNA (0.71) | POLBLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL8724983 | 0.76 | POLB (0.70) | POLBFKBP1AALDH1A1GLAKMT2A | |
| SCHEMBL27830860 | 0.76 | POLB (0.66) | POLBMAPTALDH1A1KMT2AHSD17B10 | |
| SCHEMBL3976377 | 0.74 | CA1 (0.59) | POLBFKBP1AALDH1A1GLAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8497371-B2 | Pipemidic acid derivative autotaxin inhibitors | UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION (US) | 2013-07-30 | — | — | US | disclosed |
| US-20120100592-A1 | PIPEMIDIC ACID DERIVATIVE AUTOTAXIN INHIBITORS | THE UNIVERSITY OF MEMPHIS | 2012-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120100592-A1 | PIPEMIDIC ACID DERIVATIVE AUTOTAXIN INHIBITORS | ENPP2, PLA2G6, PLA2G10 | POLB 2710/4885LMNA 1624/4885MAPT 2803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.