Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.57 |
| ▸ | IDH1 | O75874 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.47 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | HNF4A | P41235 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11781101 | 0.93 | CALM1 (0.43) | CALM1IDH1PRSS1PRSS2PRSS3 | |
| Diphenylmethane SCHEMBL6200261 | 0.85 | CALM1 (0.71) | CALM1IDH1BCL2BCL2L1IDO1 | |
| SCHEMBL23864832 | 0.83 | SLC5A2 (0.46) | CALM1IDH1IDO1SLC5A2LTA4H | |
| SCHEMBL7613502 | 0.82 | CALM1 (0.75) | CALM1IDH1PRSS1PRSS2PRSS3 | |
| SCHEMBL13971231 | 0.82 | CALM1 (0.75) | CALM1IDH1PRSS1PRSS2PRSS3 | |
| SCHEMBL25720257 | 0.80 | PNMT (0.52) | IDO1 | |
| SCHEMBL21380590 | 0.79 | BCL2 (0.36) | CALM1BCL2BCL2L1 | |
| SCHEMBL338117 | 0.77 | CALM1 (0.67) | CALM1IDH1BCL2BCL2L1HNF4A | |
| SCHEMBL22316245 | 0.76 | CYP2C19 (0.41) | IDO1 | |
| Diphenylmethane SCHEMBL14763944 | 0.76 | CALM1 (1.00) | CALM1IDH1BCL2BCL2L1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110386887-A | A kind of preparation method of 3- benzylthio phenol intermediate | 南京格亚医药科技有限公司 | 2019-10-29 | — | — | CN | claimed |
| CN-110386887-A | A kind of preparation method of 3- benzylthio phenol intermediate | 南京格亚医药科技有限公司 | 2019-10-29 | — | — | CN | disclosed |
| CN-110386887-A | A kind of preparation method of 3- benzylthio phenol intermediate | 南京格亚医药科技有限公司 | 2019-10-29 | — | — | CN | disclosed |
| CN-110386887-A | A kind of preparation method of 3- benzylthio phenol intermediate | 南京格亚医药科技有限公司 | 2019-10-29 | — | — | CN | disclosed |
| CN-104277051-B | 4 aminothiophenes simultaneously [3,2 C] carboxylic acid derivates of pyridine 7 | 霍夫曼-拉罗奇有限公司 | 2017-06-09 | — | — | CN | disclosed |
| CN-101263145-B | 4-amino-thieno [3,2-C ] pyridine-7-carboxylic acid derivatives | HOFFMANN LA ROCHE | 2015-02-25 | — | — | CN | disclosed |
| CN-104277051-A | 4-amino-thieno[3,2-c] pyridine-7-carboxylic acid derivatives | HOFFMANN LA ROCHE | 2015-01-14 | — | — | CN | disclosed |
| US-7807713-B2 | Pan-antagonists for the androgen receptor and androgen associated with anti-androgen withdrawal | UNIVERSITY OF DELAWARE (US) | 2010-10-05 | — | — | US | disclosed |
| US-20090270512-A1 | Pan-Antagonists For The Androgen Receptor And Androgen Receptor Mutants Associated With Anti-Androgen Withdrawal | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-10-29 | — | — | US | disclosed |
| US-7550505-B2 | Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal | UNIVERSITY OF DELAWARE (US) | 2009-06-23 | — | — | US | disclosed |
| CN-101263145-A | 4-amino-thieno [3, 2-C ] pyridine-7-carboxylic acid derivatives | HOFFMANN LA ROCHE (CH) | 2008-09-10 | — | — | CN | disclosed |
| US-20080064757-A1 | Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-03-13 | — | — | US | disclosed |
| WO-2008013791-A2 | PAN-ANTAGONISTS FOR THE ANDROGEN RECEPTOR AND ANDROGEN RECEPTOR MUTANTS ASSOCIATED WITH ANTI-ANDROGEN WITHDRAWAL | UNIVERSITY OF DELAWARE (US) | 2008-01-31 | — | — | WO | disclosed |
| EP-0872504-A1 | CURABLE EPOXY RESIN COMPOSITION WHICH GIVES FLEXIBLE CURED ARTICLE | ASAHI DENKA KOGYO KABUSHIKI KAISHA (JP) | 1998-10-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270512-A1 | Pan-Antagonists For The Androgen Receptor And Androgen Receptor Mutants Associated With Anti-Androgen Withdrawal | AR, NR5A1, SHBG | CALM1 4155/4885IDH1 3355/4885PRSS1 545/4885 |
| US-20080064757-A1 | Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal | AR, NR5A1, SHBG | CALM1 4155/4885IDH1 3355/4885PRSS1 545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.