Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 1/20 | 0.66 |
| ▸ | TCF4 | P15884 | 1/20 | 0.53 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 5/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GUSB | P08236 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3613333 | 0.92 | FBP1 (0.55) | FBP1TCF4CTNNB1PDE3BPDE3A | |
| SCHEMBL3440893 | 0.80 | FBP1 (0.59) | FBP1PDE3BPDE3AABCB11MAOA | |
| SCHEMBL3440919 | 0.78 | FBP1 (0.62) | FBP1PDE3BPDE3AABCB11MAOA | |
| SCHEMBL3440867 | 0.77 | FBP1 (0.56) | FBP1PDE3BPDE3AABCB11MAOA | |
| SCHEMBL3440988 | 0.77 | FBP1 (0.56) | FBP1PDE3BPDE3AABCB11MAOA | |
| SCHEMBL8767834 | 0.77 | TCF4 (0.78) | TCF4CTNNB1SIRT2SIRT1AURKA | |
| SCHEMBL3441010 | 0.77 | FBP1 (0.55) | FBP1PDE3BPDE3AABCB11MAOA | |
| SCHEMBL3614084 | 0.76 | FBP1 (0.55) | FBP1PDE3BPDE3AABCB11MAOA | |
| SCHEMBL9182933 | 0.74 | FBP1 (0.53) | FBP1PDE3BPDE3APDE4APDE4B | |
| SCHEMBL3602033 | 0.73 | FBP1 (0.59) | FBP1PDE3BPDE3AABCB11MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229385-A2 | BENZIMIDAZOLEDIHYDROTHIADIAZINONE DERIVATIVES AS FRUCTOSE-1,6-BISPHOSPHATASE INHIBITORS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | Merck Patent GmbH (DE) | 2010-09-22 | — | — | EP | claimed |
| WO-2009062576-A2 | BENZIMIDAZOLEDIHYDROTHIADIAZINONE DERIVATIVES AS FRUCTOSE-1,6-BISPHOSPHATASE INHIBITORS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | MERCK PATENT GMBH (DE) | 2009-05-22 | — | — | WO | claimed |