Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5234273 | 0.92 | LMNA (0.41) | LMNAPOLBALDH1A1TP53MAPT | |
| SCHEMBL8694588 | 0.89 | LMNA (0.40) | LMNAPOLBALDH1A1TP53MAPT | |
| SCHEMBL344172 | 0.74 | TP53 (0.44) | LMNAPOLBALDH1A1TP53MAPT | |
| SCHEMBL10866338 | 0.69 | TSHR (0.56) | ALDH1A1TP53MAPTHTTELANE | |
| SCHEMBL344259 | 0.67 | LMNA (0.66) | LMNAPOLBALDH1A1TP53MAPT | |
| SCHEMBL24330408 | 0.67 | ALDH1A1 (0.45) | LMNAALDH1A1MAPTHTTTSHR | |
| SCHEMBL109206 | 0.66 | TSHR (0.63) | ALDH1A1TP53HTTELANETSHR | |
| SCHEMBL29571304 | 0.66 | TSHR (0.63) | ALDH1A1TP53HTTELANETSHR | |
| SCHEMBL7348096 | 0.65 | TSHR (0.58) | ALDH1A1TP53HTTELANETSHR | |
| SCHEMBL6477382 | 0.64 | KMT2A (0.54) | LMNAPOLBALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804440-B1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | WYETH CORP (US) | 2007-12-19 | — | — | EP | disclosed |