Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.51 |
| ▸ | NQO2 | P16083 | 3/20 | 0.44 |
| ▸ | MYC | P01106 | 1/20 | 0.42 |
| ▸ | MAX | P61244 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | COMT | P21964 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23981 | 0.76 | MAPT (0.56) | ACHEALDH1A1KMT2AGAAMAPT | |
| SCHEMBL3181469 | 0.74 | ACHE (1.00) | ACHEALDH1A1KMT2AGAAMAPT | |
| SCHEMBL7886307 | 0.73 | NQO2 (0.61) | ALDH1A1KMT2AGAAMAPTRAB9A | |
| SCHEMBL345562 | 0.73 | ALDH1A1 (1.00) | ACHEALDH1A1KMT2AGAAMAPT | |
| SCHEMBL20475303 | 0.71 | ALDH1A1 (0.95) | ACHEALDH1A1KMT2AGAAMAPT | |
| SCHEMBL762952 | 0.71 | ACHE (0.72) | ACHEALDH1A1KMT2AGAAMAPT | |
| SCHEMBL270509 | 0.69 | MAPT (0.36) | ACHEALDH1A1KMT2AGAAMAPT | |
| SCHEMBL802228 | 0.68 | ACHE (0.61) | ACHEALDH1A1KMT2AGAAMAPT | |
| SCHEMBL13313366 | 0.68 | CYP1A2 (0.64) | ACHEALDH1A1KMT2AGAAMAPT | |
| SCHEMBL13439504 | 0.68 | ACHE (0.85) | ACHEALDH1A1KMT2AGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7812025-B2 | Brain/neuronal cell-protecting agent and therapeutic agent for sleep disorder | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-10-12 | — | — | US | disclosed |
| US-20090048263-A1 | Brain/neuronal cell-protecting agent and therapeutic agent for sleep disorder | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-02-19 | — | — | US | disclosed |
| EP-1923388-A1 | BRAIN/NEURONAL CELL-PROTECTING AGENT, AND THERAPEUTIC AGENT FOR SLEEP DISORDER | Takeda Pharmaceutical Company Limited (JP) | 2008-05-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048263-A1 | Brain/neuronal cell-protecting agent and therapeutic agent for sleep disorder | HCRTR1, HCRTR2, MTNR1A | ACHE 3601/4885ALDH1A1 738/4885KMT2A 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.