Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | HAVCR2 | Q8TDQ0 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3444475 | 0.83 | ACHE (0.46) | ACHEHAVCR2ALDH1A1KDM4EHPGD | |
| Hydrochloric Acid SCHEMBL3445384 | 0.82 | ACHE (0.45) | ACHEHAVCR2ALDH1A1KDM4EHPGD | |
| SCHEMBL958804 | 0.82 | F2RL3 (0.46) | ALDH1A1KDM4EHPGDHTTMEN1 | |
| SCHEMBL3445171 | 0.82 | MAP2K4 (0.49) | ACHEALDH1A1KDM4EHPGDHTT | |
| SCHEMBL2382846 | 0.81 | HPGD (0.37) | HAVCR2ALDH1A1KDM4EHPGDHTT | |
| SCHEMBL2384546 | 0.79 | ALDH1A1 (0.41) | ACHEALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL2386231 | 0.79 | ALDH1A1 (0.43) | ACHEALDH1A1KDM4EHPGDNPSR1 | |
| SCHEMBL3444795 | 0.78 | ALDH1A1 (0.38) | ACHEALDH1A1KDM4EHPGDHTT | |
| SCHEMBL2383613 | 0.77 | ALDH1A1 (0.41) | ACHEALDH1A1KDM4EHPGDHTT | |
| SCHEMBL2383319 | 0.76 | OPRM1 (0.41) | ALDH1A1KDM4EHPGDNPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816368-B2 | Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics | SANOFI-AVENTIS (FR) | 2010-10-19 | — | — | US | claimed |
| US-20090042924-A1 | Pyridoindolone Derivatives Substituted in the 3-position by a Heterocyclic Group, Their Preparation and Their Application in Therapeutics | SANOFI-AVENTIS (FR) | 2009-02-12 | — | — | US | claimed |
| US-7456193-B2 | Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics | SANOFI-AVENTIS (FR) | 2008-11-25 | — | — | US | claimed |
| EP-1556380-B1 | PYRIDOINDOLONE DERIVATIVES SUBSTITUTED IN THE 3-POSITION BY A HETEROCYCLIC GROUP, PREPARATION THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2006-04-12 | — | — | EP | claimed |
| US-20050222192-A1 | Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics | SANOFI-AVENTIS (FR) | 2005-10-06 | — | — | US | claimed |
| EP-1556380-A1 | PYRIDOINDOLONE DERIVATIVES SUBSTITUTED IN THE 3-POSITION BY A HETEROCYCLIC GROUP, PREPARATION THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | Sanofi-Aventis (FR) | 2005-07-27 | — | — | EP | claimed |
| WO-2004037821-A1 | PYRIDOINDOLONE DERIVATIVES SUBSTITUTED IN THE 3-POSITION BY A HETEROCYCLIC GROUP, PREPARATION THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2004-05-06 | — | — | WO | claimed |
| US-7816368-B2 | Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics | SANOFI-AVENTIS (FR) | 2010-10-19 | — | — | US | disclosed |
| US-20090042924-A1 | Pyridoindolone Derivatives Substituted in the 3-position by a Heterocyclic Group, Their Preparation and Their Application in Therapeutics | SANOFI-AVENTIS (FR) | 2009-02-12 | — | — | US | disclosed |
| US-7456193-B2 | Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics | SANOFI-AVENTIS (FR) | 2008-11-25 | — | — | US | disclosed |
| EP-1556380-B1 | PYRIDOINDOLONE DERIVATIVES SUBSTITUTED IN THE 3-POSITION BY A HETEROCYCLIC GROUP, PREPARATION THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2006-04-12 | — | — | EP | disclosed |
| US-20050222192-A1 | Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics | SANOFI-AVENTIS (FR) | 2005-10-06 | — | — | US | disclosed |
| EP-1556380-A1 | PYRIDOINDOLONE DERIVATIVES SUBSTITUTED IN THE 3-POSITION BY A HETEROCYCLIC GROUP, PREPARATION THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | Sanofi-Aventis (FR) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004037821-A1 | PYRIDOINDOLONE DERIVATIVES SUBSTITUTED IN THE 3-POSITION BY A HETEROCYCLIC GROUP, PREPARATION THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2004-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222192-A1 | Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics | CBR3, PNPO, CBR1 | ACHE 3818/4885HAVCR2 1429/4885ALDH1A1 631/4885 |
| US-20090042924-A1 | Pyridoindolone Derivatives Substituted in the 3-position by a Heterocyclic Group, Their Preparation and Their Application in Therapeutics | PNPO, DPYD, PDXK | ACHE 2298/4885HAVCR2 480/4885ALDH1A1 838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.