Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19597541 | 0.79 | ALDH1A1 (0.70) | ALDH1A1GAAPOLBL3MBTL1HSD11B1 | |
| SCHEMBL19597540 | 0.79 | ALDH1A1 (0.70) | ALDH1A1GAAPOLBL3MBTL1HSD11B1 | |
| SCHEMBL542345 | 0.78 | ALDH1A1 (0.65) | ALDH1A1GAAPOLBL3MBTL1HSD11B1 | |
| SCHEMBL21848397 | 0.78 | ALDH1A1 (0.68) | ALDH1A1GAAPOLBL3MBTL1HSD11B1 | |
| SCHEMBL392680 | 0.76 | ALDH1A1 (1.00) | ALDH1A1GAAPOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL478614 | 0.76 | ALDH1A1 (1.00) | ALDH1A1GAAPOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL30216480 | 0.76 | ALDH1A1 (1.00) | ALDH1A1GAAPOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL4861809 | 0.76 | ALDH1A1 (1.00) | ALDH1A1GAAPOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL7270800 | 0.76 | ALDH1A1 (0.74) | ALDH1A1GAAPOLBL3MBTL1HSD11B1 | |
| SCHEMBL7270796 | 0.76 | ALDH1A1 (0.74) | ALDH1A1GAAPOLBL3MBTL1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1523493-B1 | NOVEL TUBULYSIN ANALOGUES | DOEMLING ALEXANDER (DE) | 2013-09-04 | — | — | EP | disclosed |
| US-7816377-B2 | Tubulysin analogues | R&D-BIOPHARMACEUTICALS GMBH (DE) | 2010-10-19 | — | — | US | disclosed |
| US-20050239713-A1 | Novel tubulysin analogues | R&D-BIOPHARMACEUTICALS AM (DE) | 2005-10-27 | — | — | US | disclosed |
| EP-1523493-A1 | NOVEL TUBULYSIN ANALOGUES | Morphochem Aktiengesellschaft Für Kombinatorische Chemie (DE) | 2005-04-20 | — | — | EP | disclosed |
| WO-2004005327-A1 | NOVEL TUBULYSIN ANALOGUES | MORPHOCHEM AG KOMB CHEMIE (DE) | 2004-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239713-A1 | Novel tubulysin analogues | TEK, TEKT1, NGLY1 | ALDH1A1 4858/4885GAA 2193/4885POLB 4710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.