Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA1 | P02708 | 1/20 | 0.64 |
| ▸ | CHRNG | P07510 | 1/20 | 0.64 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.64 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.64 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.64 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.64 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.64 |
| ▸ | CHRND | Q07001 | 1/20 | 0.64 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | DRD3 | P35462 | 4/20 | 0.42 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 5/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4412259 | 0.78 | CHRNB2 (1.00) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL5767352 | 0.78 | CHRNB2 (0.81) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| Hydrochloric Acid SCHEMBL6392186 | 0.77 | CHRNB2 (0.78) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| Hydrochloric Acid SCHEMBL4408107 | 0.77 | CHRNB2 (0.97) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL12882856 | 0.76 | CHRNA1 (0.50) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL7399742 | 0.73 | DRD2 (0.55) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL990779 | 0.73 | DRD2 (0.55) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL912111 | 0.73 | DRD2 (0.55) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| Hydrochloric Acid SCHEMBL8690633 | 0.72 | DRD2 (0.54) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| Hydrochloric Acid SCHEMBL8904471 | 0.72 | DRD2 (0.54) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816356-B2 | Aryl and heteroaryltetrahydrocyclobutapyrroles as nicotinic acetylcholine receptor ligands | YOHANNES DANIEL | 2010-10-19 | — | — | US | disclosed |
| US-20050182063-A1 | Aryl and heteroaryltetrahydrocyclobutapyrroles as nicotinic acetylcholine receptor ligands | YOHANNES DANIEL (US) | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182063-A1 | Aryl and heteroaryltetrahydrocyclobutapyrroles as nicotinic acetylcholine receptor ligands | OPRL1, OPRK1, CHRNB4 | CHRNA1 20/4885CHRNG 19/4885CHRNB1 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.