Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.43 |
| ▸ | DAO | P14920 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11030904 | 0.78 | IDO1 (0.44) | KDM4EALDH1A1DAOHTR2CHTR2B | |
| SCHEMBL9765925 | 0.77 | TP53 (0.48) | ALDH1A1DAOSMN1; SMN2 | |
| SCHEMBL11613138 | 0.72 | KMT2A (0.47) | ALDH1A1DAOCA12CA9SMN1; SMN2 | |
| SCHEMBL10946405 | 0.71 | TRPV1 (0.53) | DAO | |
| SCHEMBL11618164 | 0.71 | DAO (0.44) | KDM4EALDH1A1CHRM5DAOP2RX3 | |
| SCHEMBL11619322 | 0.70 | MEN1 (0.50) | KDM4ECHRM5DAOHTR2CHTR2B | |
| SCHEMBL11445125 | 0.70 | P2RX3 (0.44) | KDM4EALDH1A1CHRM5DAOP2RX3 | |
| SCHEMBL14656875 | 0.69 | MGLL (0.69) | KDM4EALDH1A1CHRM5P2RX3CA12 | |
| SCHEMBL11445371 | 0.69 | KDM4E (0.41) | KDM4EALDH1A1CHRM5DAOP2RX3 | |
| SCHEMBL8404372 | 0.68 | CHRM5 (0.56) | KDM4EALDH1A1CHRM5DAOP2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260102404-A1 | THYROID STIMULATING HORMONE RECEPTOR (TSHR) ANTAGONISTS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. (US) | 2026-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260102404-A1 | THYROID STIMULATING HORMONE RECEPTOR (TSHR) ANTAGONISTS AND USES THEREOF | TSHR, TRHR, THRB | KDM4E 4836/4885ALDH1A1 3929/4885CHRM5 160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.