Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.43 |
| ▸ | STK17B | O94768 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3449434 | 0.91 | MKNK2 (0.43) | MAPK1STK17ASTK17BMKNK2GRM4 | |
| SCHEMBL3450349 | 0.88 | MAPK1 (0.44) | MAPK1STK17ASTK17BGRM4EGFR | |
| SCHEMBL3450340 | 0.84 | CSNK2A1 (0.42) | MKNK2ABCG2CSNK2A1 | |
| SCHEMBL3448165 | 0.81 | AURKA (0.46) | MKNK2EGFRABCG2CSNK1A1CSNK2A1 | |
| SCHEMBL3448169 | 0.81 | AURKA (0.46) | MKNK2EGFRABCG2CSNK1A1CSNK2A1 | |
| SCHEMBL3449350 | 0.81 | MAPK1 (0.53) | MAPK1STK17ASTK17BEGFRKDR | |
| SCHEMBL3450048 | 0.80 | RXFP1 (0.40) | MAPK1MKNK2EGFRCSNK2A1RXFP1 | |
| SCHEMBL3450701 | 0.79 | KCNN3 (0.51) | MAPK1STK17ASTK17BEGFRKDR | |
| SCHEMBL3448249 | 0.79 | MAPK1 (0.53) | MAPK1STK17ASTK17BEGFRKDR | |
| SCHEMBL3450344 | 0.79 | MAPK1 (0.40) | MAPK1STK17ASTK17BGRM4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | SDHA, SDHB, UROD | MAPK1 2905/4885STK17A 1984/4885STK17B 2457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.