SCHEMBL345016

SCHEMBL345016

O=C(Cl)c1cc(F)c(F)c(F)c1F

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.48
ALOX15 P16050 1/20 0.48
CES2 O00748 10/20 0.44
CES1 P23141 10/20 0.44
CA1 P00915 2/20 0.39
CA2 P00918 2/20 0.39
CA4 P22748 2/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
CRBN Q96SW2 1/20 0.38
KEAP1 Q14145 1/20 0.38
NFE2L2 Q16236 1/20 0.38
POLB P06746 1/20 0.33
APEX1 P27695 1/20 0.33
BCHE P06276 1/20 0.33
HPGD P15428 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7729918 0.89 CES2 (0.57) ALDH1A1ALOX15CES2CES1CA1
SCHEMBL8072641 0.84 ALDH1A1 (0.43) ALDH1A1ALOX15CES2CES1CA1
SCHEMBL6324748 0.84 ALDH1A1 (0.43) ALDH1A1ALOX15CES2CES1CA1
SCHEMBL1408469 0.82 ALDH1A1 (0.42) ALDH1A1ALOX15CES2CES1CA1
SCHEMBL4851418 0.82 CES2 (0.46) CES2CES1CA1CA2CA4
Fluoride SCHEMBL28471026 0.82 CES2 (0.46) CES2CES1CA1CA2CA4
SCHEMBL24710385 0.81 ALDH1A1 (0.54) ALDH1A1ALOX15CES2CES1CA1
SCHEMBL28525271 0.81 ALDH1A1 (0.54) ALDH1A1ALOX15CES2CES1CA1
SCHEMBL29690316 0.81 ALDH1A1 (0.45) ALDH1A1ALOX15CES2CES1CA1
SCHEMBL8160121 0.81 ALDH1A1 (0.45) ALDH1A1ALOX15CES2CES1CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 522 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120079241-A Preparation method of polyamide solvent-resistant nanofiltration membrane with high crosslinking degree 天津理工大学 2025-06-03 CN claimed
CN-119504581-A Method for efficiently synthesizing marbofloxacin key intermediate 江苏恒盛药业有限公司 2025-02-25 CN claimed
CN-119500004-A Production system of oxyfluoro cyclic ester 江西省驰邦药业有限公司 2025-02-25 CN claimed
CN-112552261-B Preparation method of levofloxacin and intermediate thereof 宜昌东阳光长江药业股份有限公司 2024-11-08 CN claimed
CN-112552260-B Preparation method of levofloxacin and intermediate thereof 宜昌东阳光长江药业股份有限公司 2024-11-08 CN claimed
CN-115703757-B Synthesis method of melaxacin 浙江中欣氟材股份有限公司 2024-04-09 CN claimed
CN-114315561-B Method for synthesizing 2,3,4, 5-tetrafluorobenzoyl chloride 内蒙古源宏精细化工有限公司 2023-10-24 CN claimed
CN-116845345-A Preparation method of gel quasi-solid electrolyte, gel quasi-solid electrolyte and lithium ion battery 阜新德尔汽车部件股份有限公司 2023-10-03 CN claimed
CN-115991644-B Preparation method of 2,3,4, 5-tetrafluorobenzoyl chloride 山东京新药业有限公司 2023-06-20 CN claimed
CN-115991644-A Preparation method of 2,3,4, 5-tetrafluorobenzoyl chloride 山东京新药业有限公司 2023-04-21 CN claimed
EP-0680482-A1 PROCESS FOR THE MANUFACTURE OF A TRICYCLIC COMPOUND. PFIZER (US) 1995-11-08 EP claimed
WO-1994017074-A1 PROCESS FOR THE MANUFACTURE OF A TRICYCLIC COMPOUND PFIZER INC. (US) 1994-08-04 WO claimed
EP-0236673-B1 Process for quinoline-3-carboxylic acid antibacterial agents WARNER LAMBERT CO (US) 1994-07-13 EP claimed
US-4948894-A BACTERICIDE INTERMEDIATES AMERICAN CYANAMID COMPANY (US) 1990-08-14 US claimed
EP-0239992-B1 PROCESS FOR THE PREPARATION OF 2,3,4,5-TETRAFLUOROBENZOYL ACETATES WARNER-LAMBERT COMPANY (US) 1989-09-06 EP claimed
US-4772706-A Process for quinoline-3-carboxylic acid antibacterial agents WARNER-LAMBERT COMPANY (US) 1988-09-20 US claimed
EP-0239992-A1 Process for the preparation of 2,3,4,5-tetrafluorobenzoyl acetates WARNER-LAMBERT COMPANY (US) 1987-10-07 EP claimed
EP-0236673-A2 Process for quinoline-3-carboxylic acid antibacterial agents WARNER-LAMBERT COMPANY (US) 1987-09-16 EP claimed
EP-0126355-B1 7-AMINO-1-CYCLOPROPYL-6,8-DIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE-CARBOXYLIC ACID, PROCESSES FOR THEIR PREPARATION AND ANTIBACTERIAL AGENTS CONTAINING THEM BAYER AG (DE) 1987-09-09 EP claimed
US-4689423-A Process for the preparation of 2,3,4,5-tetrafluorobenzoyl acetates WARNER-LAMBERT COMPANY (US) 1987-08-25 US claimed