SCHEMBL7729918

SCHEMBL7729918

O=C(Cl)c1cc(F)c(F)c(F)c1F.O=C(Cl)c1ccc(F)c(F)c1F

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CES2 O00748 9/20 0.57
CES1 P23141 9/20 0.57
ALDH1A1 P00352 1/20 0.45
ALOX15 P16050 1/20 0.45
BCHE P06276 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
PIK3CA P42336 1/20 0.34
MAP2K1 Q02750 3/20 0.34
CRBN Q96SW2 1/20 0.34
MAP2K2 P36507 2/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA4 P22748 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL525011 0.92 CES2 (0.67) CES2CES1ALDH1A1ALOX15BCHE
SCHEMBL345016 0.89 ALDH1A1 (0.48) CES2CES1ALDH1A1ALOX15BCHE
SCHEMBL7728912 0.89 CES2 (0.53) CES2CES1ALDH1A1ALOX15BCHE
SCHEMBL8703978 0.80 CES2 (0.48) CES2CES1ALDH1A1ALOX15MEN1
SCHEMBL8093617 0.76 CES2 (0.43) CES2CES1ALDH1A1ALOX15KMT2A
SCHEMBL6324748 0.75 ALDH1A1 (0.43) CES2CES1ALDH1A1ALOX15PIK3CA
SCHEMBL8072641 0.75 ALDH1A1 (0.43) CES2CES1ALDH1A1ALOX15BCHE
SCHEMBL1774412 0.75 ALDH1A1 (0.48) CES2CES1ALDH1A1ALOX15BCHE
SCHEMBL9860898 0.75 CES2 (0.50) CES2CES1ALDH1A1ALOX15BCHE
SCHEMBL1408469 0.73 ALDH1A1 (0.42) CES2CES1ALDH1A1ALOX15SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1015479-A4 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC MACROCYCLES AND PROCESSES THEREFOR LILLY CO ELI (US) 2002-07-24 EP disclosed
EP-1015479-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC MACROCYCLES AND PROCESSES THEREFOR ELI LILLY AND COMPANY (US) 2000-07-05 EP disclosed
WO-1998046631-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC MACROCYCLES AND PROCESSES THEREFOR ELI LILLY AND COMPANY (US) 1998-10-22 WO disclosed
WO-1998008813-A1 COMBINATORIAL PROCESS FOR PREPARING SUBSTITUTED PYRROLIDINE LIBRARIES ELI LILLY AND COMPANY (US) 1998-03-05 WO disclosed