Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 3/20 | 0.39 |
| ▸ | CES1 | P23141 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 9/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 9/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7813170 | 0.84 | HSD17B1 (0.45) | ALDH1A1ALOX15CES2CES1HSD17B1 | |
| SCHEMBL345016 | 0.84 | ALDH1A1 (0.48) | ALDH1A1ALOX15CES2CES1CA1 | |
| SCHEMBL6324251 | 0.80 | AKR1C2 (0.48) | ALDH1A1CES2CES1CA1CA2 | |
| SCHEMBL155657 | 0.78 | KMT2A (0.41) | ALDH1A1CES2CES1CA1CA2 | |
| SCHEMBL8072641 | 0.78 | ALDH1A1 (0.43) | ALDH1A1ALOX15CES2CES1CA1 | |
| SCHEMBL1408469 | 0.77 | ALDH1A1 (0.42) | ALDH1A1ALOX15CES2CES1CA1 | |
| SCHEMBL24710385 | 0.76 | ALDH1A1 (0.54) | ALDH1A1ALOX15CES2CES1CA1 | |
| SCHEMBL28525271 | 0.76 | ALDH1A1 (0.54) | ALDH1A1ALOX15CES2CES1CA1 | |
| SCHEMBL8160121 | 0.76 | ALDH1A1 (0.45) | ALDH1A1ALOX15CES2CES1CA1 | |
| SCHEMBL29690316 | 0.76 | ALDH1A1 (0.45) | ALDH1A1ALOX15CES2CES1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050124664-A1 | Urea thiadiazole inhibitors of plasminogen activator inhibior-1 | BRISTOL-MYERS SQUIBB CO. | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124664-A1 | Urea thiadiazole inhibitors of plasminogen activator inhibior-1 | SERPINE1, SERPINC1, SERPINB1 | ALDH1A1 155/4885ALOX15 1940/4885CES2 3089/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.