SCHEMBL345078

SCHEMBL345078

CCOC(=O)c1cc(COC(=O)N(Cc2ccc3cc(Cl)ccc3n2)C2(F)CCNCC2)on1

nearest known ligand 0.34

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.34
MRGPRX4 Q96LA9 1/20 0.34
MAPT P10636 5/20 0.34
MAPK1 P28482 2/20 0.32
RAB9A P51151 2/20 0.32
KMT2A Q03164 2/20 0.32
LMNA P02545 2/20 0.32
CYP19A1 P11511 1/20 0.32
ALOX15 P16050 1/20 0.32
KCNH2 Q12809 1/20 0.32
HRH3 Q9Y5N1 1/20 0.32
P2RX3 P56373 1/20 0.31
POLB P06746 1/20 0.31
ALDH1A1 P00352 1/20 0.31
ANO1 Q5XXA6 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2327807 0.91 FAAH (0.32) MRGPRX4MAPTMAPK1RAB9ALMNA
SCHEMBL344923 0.79 RAB9A (0.34) L3MBTL1MAPTRAB9AKMT2ALMNA
Trifluoroacetic Acid SCHEMBL345530 0.72 KMT2A (0.34) L3MBTL1MAPTRAB9AKMT2ALMNA
SCHEMBL345082 0.71 F10 (0.41) L3MBTL1MRGPRX4MAPTRAB9ALMNA
SCHEMBL345077 0.70 HTR3A (0.39) L3MBTL1MRGPRX4MAPTRAB9AKMT2A
SCHEMBL2329304 0.69 TACR1 (0.30) KCNH2POLB
SCHEMBL345079 0.69 MAPT (0.36) L3MBTL1MAPTMAPK1LMNAALOX15
SCHEMBL9993053 0.67 MC4R (0.38) MAPTMAPK1RAB9AKMT2ALMNA
SCHEMBL2324595 0.66 L3MBTL1 (0.32) L3MBTL1MAPTRAB9AKMT2ALMNA
SCHEMBL345081 0.66 ACACB (0.41) L3MBTL1MRGPRX4MAPTRAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8716289-B2 Carbamate derivatives of alkyl-heterocycles, preparation thereof and therapeutic use thereof SANOFI (FR) 2014-05-06 US disclosed
US-20120015950-A1 CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2012-01-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120015950-A1 CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF INTS9, CDK8, SCN8A L3MBTL1 3990/4885MRGPRX4 1323/4885MAPT 4026/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.