Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 4/20 | 0.44 |
| ▸ | INSR | P06213 | 3/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 5/20 | 0.43 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 3/20 | 0.40 |
| ▸ | GLP1R | P43220 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3447570 | 0.91 | PAK1 (0.46) | METINSRAXLPAK1EGFR | |
| SCHEMBL3449427 | 0.89 | AXL (0.50) | CSNK2A1AXLPAK1EGFR | |
| SCHEMBL3449234 | 0.86 | XDH (0.43) | CSNK2A1AXLPAK1EGFRMERTK | |
| SCHEMBL3447674 | 0.86 | JAK3 (0.43) | CSNK2A1AXLPAK1EGFRMERTK | |
| SCHEMBL3449090 | 0.86 | ALK (0.47) | CSNK2A1AXLEGFRSYKALK | |
| SCHEMBL3451174 | 0.85 | JAK3 (0.44) | CSNK2A1AXLPAK1EGFRMERTK | |
| SCHEMBL3447741 | 0.85 | JAK3 (0.44) | CSNK2A1AXLPAK1EGFRMERTK | |
| SCHEMBL3450574 | 0.85 | F11 (0.44) | CSNK2A1PAK1EGFR | |
| SCHEMBL3450592 | 0.84 | CSNK2A1 (0.42) | CSNK2A1AXLPAK1EGFRSYK | |
| SCHEMBL3450200 | 0.84 | SMN1; SMN2 (0.44) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | SDHA, SDHB, UROD | MET 3698/4885INSR 3066/4885CSNK2A1 1858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.