Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.56 |
| ▸ | MAOA | P21397 | 2/20 | 0.56 |
| ▸ | PRKCI | P41743 | 1/20 | 0.56 |
| ▸ | RXRA | P19793 | 3/20 | 0.47 |
| ▸ | MIF | P14174 | 6/20 | 0.44 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3451818 | 1.00 | MAOB (0.56) | MAOBMAOAPRKCIRXRAMIF | |
| SCHEMBL15520690 | 0.83 | CAMK2A (0.55) | RXRACYP19A1 | |
| SCHEMBL15520691 | 0.83 | CAMK2A (0.55) | RXRACYP19A1 | |
| SCHEMBL6812185 | 0.79 | CYP19A1 (0.52) | MAOBMAOARXRAMIFCYP19A1 | |
| SCHEMBL6812188 | 0.79 | CYP19A1 (0.52) | MAOBMAOARXRAMIFCYP19A1 | |
| SCHEMBL3450465 | 0.79 | CYP19A1 (0.56) | RXRAMIFCYP26A1CYP19A1ESR1 | |
| SCHEMBL3450462 | 0.79 | CYP19A1 (0.56) | RXRAMIFCYP26A1CYP19A1ESR1 | |
| SCHEMBL14563379 | 0.79 | MAOA (0.47) | MAOBMAOAPRKCIRXRAMIF | |
| SCHEMBL8923628 | 0.78 | RXRA (0.60) | MAOBMAOARXRAMIFCYP19A1 | |
| SCHEMBL8923632 | 0.78 | RXRA (0.60) | MAOBMAOARXRAMIFCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820837-B2 | ethyl {6-[(3-phenoxybenzyl)oxy]-3,4-dihydronaphthalen-1-yl}acetate; having a GPR40 receptor function modulating action and being useful as an insulin secretagogue or a pharmaceutical agent for the prophylaxis or treatment of diabetes | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-10-26 | — | — | US | disclosed |
| EP-1630152-A1 | CONDENSED RING COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2006-03-01 | — | — | EP | disclosed |