Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3458513 | 0.74 | SMN1; SMN2 (0.46) | PNMTL3MBTL1TSHRMAPK1LMNA | |
| SCHEMBL18838970 | 0.67 | IKBKB (0.32) | MAPK1 | |
| SCHEMBL13726427 | 0.66 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1TDP1TSHRKDM4E | |
| SCHEMBL3171440 | 0.66 | PNMT (0.68) | PNMTHTR2CHTR2ATAAR1ADRA2A | |
| SCHEMBL31158975 | 0.66 | PNMT (0.68) | PNMTHTR2CHTR2ATAAR1ADRA2A | |
| Bromide SCHEMBL15466167 | 0.66 | L3MBTL1 (0.48) | L3MBTL1ALDH1A1TDP1TSHRKDM4E | |
| Hydrochloric Acid SCHEMBL1636223 | 0.65 | PNMT (0.66) | PNMTHTR2CTAAR1ADRA2ACYP2D6 | |
| SCHEMBL30963678 | 0.65 | BRPF1 (0.44) | L3MBTL1ALDH1A1TSHRKDM4EHPGD | |
| SCHEMBL2731241 | 0.65 | BRPF1 (0.44) | L3MBTL1ALDH1A1TSHRKDM4EHPGD | |
| SCHEMBL1647079 | 0.64 | PNMT (0.46) | PNMTADRB1HTR2CHTR2ANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820650-B2 | Antifungal 4-substituted 5,6-dihydro-4H-pyrrolo [1,2-a][1,4]benzodiazepines | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-26 | — | — | US | disclosed |
| EP-1392691-B1 | ANTIFUNGAL 4-SUBSTITUTED 5,6-DIHYDRO-4H-PYRROLO[1,2-A] [1,4] BENZODIAZEPINES | JANSSEN PHARMACEUTICA NV (BE) | 2009-05-20 | — | — | EP | disclosed |
| US-20070232593-A1 | ANTIFUNGAL 4-SUBSTITUTED 5,6-DIHYDRO-4H-PYRROLO [1,2-a][1,4]BENZODIAZEPINES | GILKERSON TERENCE | 2007-10-04 | — | — | US | disclosed |
| US-7202240-B2 | Antifungal 4-substituted 5,6-dihydro-4h-pyrrolo[1,2-a][1,4] benzodiazepines | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-10 | — | — | US | disclosed |
| US-20040266756-A1 | Antifungal 4-substituted 5,6-dihydro-4h-pyrrolo[1,2-a][1,4] benzodiazepines | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-12-30 | — | — | US | disclosed |
| EP-1392691-A1 | ANTIFUNGAL 4-SUBSTITUTED 5,6-DIHYDRO-4 u H /u -PYRROLO 1,2-A] 1,4]BENZODIAZEPINES | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002034752-A1 | ANTIFUNGAL 4-SUBSTITUTED 5,6-DIHYDRO-4H-PYRROLO[1,2-A][1,4]BENZODIAZEPINES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232593-A1 | ANTIFUNGAL 4-SUBSTITUTED 5,6-DIHYDRO-4H-PYRROLO [1,2-a][1,4]BENZODIAZEPINES | GABBR1, HRH4, CYP8B1 | PNMT 984/4885ADRB1 111/4885DRD2 186/4885 |
| US-20040266756-A1 | Antifungal 4-substituted 5,6-dihydro-4h-pyrrolo[1,2-a][1,4] benzodiazepines | CYP1B1, CBR1, CYP2E1 | PNMT 523/4885ADRB1 43/4885DRD2 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.