Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ATM | Q13315 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | OXTR | P30559 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | CD44 | P16070 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1864058 | 0.76 | SMN1; SMN2 (0.40) | SMN1; SMN2TSHRMAPK1L3MBTL1MEN1 | |
| SCHEMBL29482380 | 0.76 | SMN1; SMN2 (0.40) | SMN1; SMN2TSHRMAPK1L3MBTL1MEN1 | |
| Hydrochloric Acid SCHEMBL7340954 | 0.75 | SMN1; SMN2 (0.42) | SMN1; SMN2TSHRMAPK1L3MBTL1MEN1 | |
| SCHEMBL3452730 | 0.74 | PNMT (0.41) | TSHRMAPK1L3MBTL1LMNAHSD17B10 | |
| SCHEMBL30963678 | 0.72 | BRPF1 (0.44) | SMN1; SMN2TSHRMAPK1L3MBTL1MEN1 | |
| Hydroxyamine SCHEMBL9656518 | 0.72 | TSHR (0.37) | SMN1; SMN2TSHRMAPK1L3MBTL1MEN1 | |
| SCHEMBL2731241 | 0.72 | BRPF1 (0.44) | SMN1; SMN2TSHRMAPK1L3MBTL1MEN1 | |
| SCHEMBL9654083 | 0.71 | PNMT (0.32) | PNMT | |
| SCHEMBL18838970 | 0.71 | IKBKB (0.32) | MAPK1ATM | |
| SCHEMBL13125562 | 0.70 | SMN1; SMN2 (0.36) | SMN1; SMN2TSHRMAPK1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024102999-A2 | SMALL MOLECULE INHIBITORS FOR THE TREATMENT AND PREVENTION OF CORONAVIRUS INFECTIONS | OHIO STATE INNOVATION FOUNDATION (US) | 2024-05-16 | — | — | WO | disclosed |
| CN-106674226-B | Antifungal compounds substituted with heterocyclic derivatives | 詹森药业有限公司 | 2020-05-26 | — | — | CN | disclosed |
| US-9975899-B2 | Antifungal 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzo-diazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-22 | — | — | US | disclosed |
| US-9975899-B2 | Antifungal 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzo-diazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-22 | — | — | US | disclosed |
| US-9975899-B2 | Antifungal 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzo-diazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-22 | — | — | US | disclosed |
| US-9975899-B2 | Antifungal 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzo-diazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-22 | — | — | US | disclosed |
| CN-106674226-A | NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO-DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES | 詹森药业有限公司 | 2017-05-17 | — | — | CN | disclosed |
| CN-106674226-A | NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO-DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES | 詹森药业有限公司 | 2017-05-17 | — | — | CN | disclosed |
| US-9637490-B2 | Antifungal 5,6-dihydro-4-[(difluoroethyl)phenyl]-4H-pyrrolo[1,2-α][1,4]benzodiazepine and 4-(difluoroethyl)phenyl-6H-pyrrolo[1,2-α][1,4]benzodiazepine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-02 | — | — | US | disclosed |
| US-9637490-B2 | Antifungal 5,6-dihydro-4-[(difluoroethyl)phenyl]-4H-pyrrolo[1,2-α][1,4]benzodiazepine and 4-(difluoroethyl)phenyl-6H-pyrrolo[1,2-α][1,4]benzodiazepine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-02 | — | — | US | disclosed |
| EP-1392691-B1 | ANTIFUNGAL 4-SUBSTITUTED 5,6-DIHYDRO-4H-PYRROLO[1,2-A] [1,4] BENZODIAZEPINES | JANSSEN PHARMACEUTICA NV (BE) | 2009-05-20 | — | — | EP | disclosed |
| EP-1392691-B1 | ANTIFUNGAL 4-SUBSTITUTED 5,6-DIHYDRO-4H-PYRROLO[1,2-A] [1,4] BENZODIAZEPINES | JANSSEN PHARMACEUTICA NV (BE) | 2009-05-20 | — | — | EP | disclosed |
| US-20070232593-A1 | ANTIFUNGAL 4-SUBSTITUTED 5,6-DIHYDRO-4H-PYRROLO [1,2-a][1,4]BENZODIAZEPINES | GILKERSON TERENCE | 2007-10-04 | — | — | US | disclosed |
| US-20070232593-A1 | ANTIFUNGAL 4-SUBSTITUTED 5,6-DIHYDRO-4H-PYRROLO [1,2-a][1,4]BENZODIAZEPINES | GILKERSON TERENCE | 2007-10-04 | — | — | US | disclosed |
| US-7202240-B2 | Antifungal 4-substituted 5,6-dihydro-4h-pyrrolo[1,2-a][1,4] benzodiazepines | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-10 | — | — | US | disclosed |
| US-7202240-B2 | Antifungal 4-substituted 5,6-dihydro-4h-pyrrolo[1,2-a][1,4] benzodiazepines | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-10 | — | — | US | disclosed |
| US-20040266756-A1 | Antifungal 4-substituted 5,6-dihydro-4h-pyrrolo[1,2-a][1,4] benzodiazepines | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-12-30 | — | — | US | disclosed |
| EP-1392691-A1 | ANTIFUNGAL 4-SUBSTITUTED 5,6-DIHYDRO-4 u H /u -PYRROLO 1,2-A] 1,4]BENZODIAZEPINES | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002034752-A1 | ANTIFUNGAL 4-SUBSTITUTED 5,6-DIHYDRO-4H-PYRROLO[1,2-A][1,4]BENZODIAZEPINES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-05-02 | — | — | WO | disclosed |
| WO-2002034752-A1 | ANTIFUNGAL 4-SUBSTITUTED 5,6-DIHYDRO-4H-PYRROLO[1,2-A][1,4]BENZODIAZEPINES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232593-A1 | ANTIFUNGAL 4-SUBSTITUTED 5,6-DIHYDRO-4H-PYRROLO [1,2-a][1,4]BENZODIAZEPINES | GABBR1, HRH4, CYP8B1 | SMN1; SMN2 4847/4885TSHR 892/4885MAPK1 2422/4885 |
| US-20040266756-A1 | Antifungal 4-substituted 5,6-dihydro-4h-pyrrolo[1,2-a][1,4] benzodiazepines | CYP1B1, CBR1, CYP2E1 | SMN1; SMN2 4729/4885TSHR 1721/4885MAPK1 939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.