Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | F3 | P13726 | 4/20 | 0.50 |
| ▸ | MLYCD | O95822 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 3/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3033837 | 0.86 | KMT2A (0.61) | KMT2AGAAHSD17B10HPGDKDM4E | |
| SCHEMBL16866256 | 0.84 | GAA (0.68) | KMT2AGAAHSD17B10HPGDKDM4E | |
| SCHEMBL3028838 | 0.81 | KMT2A (0.63) | KMT2AGAAHSD17B10HPGDKDM4E | |
| SCHEMBL3453839 | 0.78 | HPGD (0.55) | KMT2AHPGDKDM4EPRSS1LCK | |
| SCHEMBL17865783 | 0.78 | MLYCD (0.73) | KMT2AGAAHSD17B10HPGDKDM4E | |
| SCHEMBL6273049 | 0.77 | GAA (0.66) | KMT2AGAAHSD17B10HPGDKDM4E | |
| SCHEMBL5482854 | 0.77 | GAA (0.61) | KMT2AGAAHSD17B10HPGDKDM4E | |
| SCHEMBL10324044 | 0.77 | HPGD (0.71) | KMT2AGAAHSD17B10HPGDKDM4E | |
| SCHEMBL3946696 | 0.76 | KDM4E (0.75) | KMT2AGAAHSD17B10HPGDKDM4E | |
| SCHEMBL30935786 | 0.76 | LCK (0.75) | KMT2AHSD17B10KDM4EPRSS1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205070-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2010-07-14 | — | — | EP | claimed |
| WO-2009045385-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2009-04-09 | — | — | WO | claimed |