Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13541870 | 0.89 | ALDH1A1 (0.49) | ALDH1A1ACACBLMNATSHRHTT | |
| SCHEMBL3455839 | 0.87 | HTT (0.46) | ALDH1A1PDE2APTGER4ACACBNPC1 | |
| SCHEMBL3454459 | 0.80 | SCD (0.55) | LMNAHTT | |
| SCHEMBL3447237 | 0.78 | SCD (0.56) | ALDH1A1NPC1LMNA | |
| SCHEMBL13541863 | 0.77 | ALDH1A1 (0.58) | ALDH1A1PDE2AGABRA5MAOANPC1 | |
| SCHEMBL3454764 | 0.76 | SCD (0.44) | ALDH1A1NPC1KMT2ALMNA | |
| SCHEMBL3455193 | 0.72 | ATM (0.46) | NPC1KMT2AHTT | |
| SCHEMBL13494840 | 0.71 | NPC1 (0.74) | ALDH1A1MAOANPC1KMT2ALMNA | |
| SCHEMBL3454348 | 0.70 | SCD (0.55) | — | |
| SCHEMBL16190459 | 0.70 | ACACB (0.55) | ALDH1A1ACACBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010007482-A2 | THIAZOLE DERIVATIVES AS STEAROYL COA DESATURASE INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2010-01-21 | — | — | WO | claimed |
| WO-2010007482-A2 | THIAZOLE DERIVATIVES AS STEAROYL COA DESATURASE INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2010-01-21 | — | — | WO | disclosed |
| WO-2010007482-A2 | THIAZOLE DERIVATIVES AS STEAROYL COA DESATURASE INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2010-01-21 | — | — | WO | disclosed |