SCHEMBL345578

SCHEMBL345578

O=C(O)CNC(F)(F)CF

nearest known ligand 0.36

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
LDHA P00338 1/20 0.33
SRR Q9GZT4 1/20 0.33
CTH P32929 1/20 0.31
ACLY P53396 2/20 0.30
EGLN1 Q9GZT9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL345431 0.77 FFAR3 (0.36) LDHASRRCTHEGLN1
SCHEMBL14308662 0.75
SCHEMBL18509324 0.72 FFAR3 (0.32) CTHEGLN1
SCHEMBL1345887 0.70
Oxalic Acid SCHEMBL4239026 0.68 ALOX15 (0.34)
Norflurane SCHEMBL5935148 0.65 CASP1 (0.35) LDHASRRACLYEGLN1
SCHEMBL707887 0.65
SCHEMBL967609 0.65
SCHEMBL2804137 0.63 EGLN1 (0.39) LDHASRRCTHACLYEGLN1
SCHEMBL345581 0.63 EGLN1 (0.33) LDHASRRCTHACLYEGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3893934-B1 INSULIN CONJUGATES SANOFI SA (FR) 2025-09-10 EP disclosed
US-20250206798-A1 INSULIN CONJUGATES SANOFI SA (FR) 2025-06-26 US disclosed
US-12195510-B2 Insulin conjugates SANOFI (FR) 2025-01-14 US disclosed
US-20220048968-A1 INSULIN CONJUGATES SANOFI (FR) 2022-02-17 US disclosed
EP-3894435-A1 INSULIN ANALOGS HAVING REDUCED INSULIN RECEPTOR BINDING AFFINITY SANOFI (FR) 2021-10-20 EP disclosed
EP-3893934-A1 INSULIN CONJUGATES SANOFI (FR) 2021-10-20 EP disclosed
WO-2020120477-A1 INSULIN ANALOGS HAVING REDUCED INSULIN RECEPTOR BINDING AFFINITY SANOFI (FR) 2020-06-18 WO disclosed
WO-2020120463-A1 INSULIN CONJUGATES SANOFI (FR) 2020-06-18 WO disclosed
US-20200181223-A1 INSULIN CONJUGATES SANOFI (FR) 2020-06-11 US disclosed
US-8809498-B2 Pepstatin A derivatives FREIE UNIVERSITAET BERLIN (DE) 2014-08-19 US disclosed
EP-2283030-B1 PEPSTATIN A DERIVATIVES UNIV BERLIN FREIE (DE) 2013-10-23 EP disclosed
US-20120016103-A1 PEPSTATIN A DERIVATIVES FREIE UNIVERSITAET BERLIN 2012-01-19 US disclosed
EP-2283030-A1 PEPSTATIN A DERIVATIVES Freie Universität Berlin (DE) 2011-02-16 EP disclosed
WO-2009133188-A1 PEPSTATIN A DERIVATIVES FREIE UNIVERSITÄT BERLIN (DE) 2009-11-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200181223-A1 INSULIN CONJUGATES IAPP, INSR, IGF1R LDHA 1277/4885SRR 1899/4885CTH 486/4885
US-20220048968-A1 INSULIN CONJUGATES IAPP, INSR, IGF1R LDHA 1277/4885SRR 1899/4885CTH 486/4885
US-20120016103-A1 PEPSTATIN A DERIVATIVES PEPD, ANPEP, VIP LDHA 3118/4885SRR 3452/4885CTH 3106/4885
US-12195510-B2 Insulin conjugates IAPP, INSR, IGF1R LDHA 1277/4885SRR 1899/4885CTH 486/4885
US-20250206798-A1 INSULIN CONJUGATES IAPP, INSR, IGF1R LDHA 1277/4885SRR 1899/4885CTH 486/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.