SCHEMBL3457151

SCHEMBL3457151

Cc1cc(Cl)c(C(=O)NCc2ncc(Cl)cc2Cl)c(Cl)c1

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 2/20 0.41
HPGD P15428 2/20 0.39
RAB9A P51151 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
POLB P06746 1/20 0.38
EPHX2 P34913 1/20 0.36
MAPK1 P28482 2/20 0.36
BACE1 P56817 1/20 0.36
TSHR P16473 1/20 0.36
P2RX3 P56373 1/20 0.36
P2RX2 Q9UBL9 1/20 0.36
MAPT P10636 1/20 0.36
KLKB1 P03952 1/20 0.35
MAP4K1 Q92918 1/20 0.35
NR3C1 P04150 2/20 0.35
LMNA P02545 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3457802 0.84 POLB (0.55) P2RX7HPGDPOLBTSHR
SCHEMBL6029625 0.84 KMT2A (0.43) P2RX7HPGDMEN1KMT2APOLB
SCHEMBL3457425 0.83 CYP1A2 (0.49) RAB9AMEN1KMT2AMAPK1MAPT
SCHEMBL10140121 0.82 POLB (0.52) P2RX7HPGDRAB9AKMT2APOLB
SCHEMBL6030405 0.78 P2RX7 (0.43) P2RX7HPGDMEN1KMT2APOLB
SCHEMBL6030456 0.75 MEN1 (0.39) HPGDMEN1KMT2APOLBMAPK1
SCHEMBL6905404 0.72 TAAR1 (0.43) P2RX7RAB9AMEN1KMT2APOLB
SCHEMBL6481161 0.72 MEN1 (0.39) HPGDMEN1KMT2APOLBMAPK1
SCHEMBL3457566 0.71 S1PR3 (0.40) MEN1KMT2AP2RX3P2RX2
SCHEMBL6888143 0.71 POLB (0.46) P2RX7HPGDRAB9AMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1484970-B1 BENZAMIDES AND COMPOSITIONS COMPRISING BENZAMIDES FOR USE AS FUNGICIDES DU PONT (US) 2013-06-26 EP claimed
EP-2260704-B1 Fungicidal compositions comprising a benzamide and cymoxanil DU PONT (US) 2013-10-16 EP disclosed
EP-1484970-B1 BENZAMIDES AND COMPOSITIONS COMPRISING BENZAMIDES FOR USE AS FUNGICIDES DU PONT (US) 2013-06-26 EP disclosed
EP-2260705-A2 Fungicidal compositions comprising a benzamide and a michondrial respiration inhibitor E. I. du Pont de Nemours and Company (US) 2010-12-15 EP disclosed
EP-2260703-A2 Fungicidal compositions comprising a benzamide and fosetyl-aluminium E. I. du Pont de Nemours and Company (US) 2010-12-15 EP disclosed
EP-2260704-A2 Fungicidal compositions comprising a benzamide and cymoxanil E. I. du Pont de Nemours and Company (US) 2010-12-15 EP disclosed
EP-2258190-A2 Fungicidal compositions comprising a benzamide and a phthalimide E. I. du Pont de Nemours and Company (US) 2010-12-08 EP disclosed
US-20050164999-A1 Benzamides and compositions benzamides for use as fungicizide E. I. DU PONT DE NEMOURS AND COMPANY 2005-07-28 US disclosed
EP-1484970-A2 BENZAMIDES AND COMPOSITIONS COMPRISING BENZAMIDES FOR USE AS FUNGICIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2004-12-15 EP disclosed
WO-2003079788-A2 BENZAMIDES AND COMPOSITIONS BENZAMIDES FOR USE AS FUNGIZIDE E.I. DU PONT DE NEMOURS AND COMPANY (US) 2003-10-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050164999-A1 Benzamides and compositions benzamides for use as fungicizide CYC1, ME3, ME2 P2RX7 2732/4885HPGD 2181/4885RAB9A 2816/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.