Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXTR | P30559 | 3/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 12/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | FASN | P49327 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3457605 | 0.72 | ADAM10 (0.39) | OXTREGLN1CYP11B1CYP11B2AVPR1A | |
| SCHEMBL3457000 | 0.72 | EGLN1 (0.39) | EGLN1FASN | |
| SCHEMBL3457871 | 0.69 | FASN (0.40) | EGLN1HRH2HRH1FASNKMT2A | |
| SCHEMBL3457329 | 0.66 | KDM1A (0.40) | EGLN1CYP11B1CYP11B2FASN | |
| Hydrochloric Acid SCHEMBL2171943 | 0.64 | HTR6 (0.59) | CYP11B1CYP11B2KMT2A | |
| SCHEMBL5321408 | 0.64 | HTR6 (0.59) | CYP11B1CYP11B2KMT2A | |
| SCHEMBL3457210 | 0.64 | CYP11B2 (0.37) | EGLN1CYP11B1CYP11B2HRH2HRH1 | |
| SCHEMBL2154193 | 0.60 | CYP11B2 (0.53) | CYP11B1CYP11B2SLC22A12 | |
| SCHEMBL3121523 | 0.58 | CYP11B2 (0.44) | CYP11B1CYP11B2SLC22A12 | |
| SCHEMBL6359772 | 0.58 | NAMPT (0.42) | CYP11B1CYP11B2HRH2HRH1SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264030-A1 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | Incyte Corporation (US) | 2010-12-22 | — | — | EP | disclosed |