Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 3/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3457329 | 0.88 | KDM1A (0.40) | FASNEGLN1RORC | |
| SCHEMBL3457875 | 0.74 | NAMPT (0.51) | EGLN1ALKHRH2HRH1KDM4E | |
| SCHEMBL3457000 | 0.74 | EGLN1 (0.39) | FASNEGLN1KDM4EGLAHPGD | |
| SCHEMBL3457601 | 0.69 | OXTR (0.38) | FASNEGLN1HRH2HRH1KMT2A | |
| SCHEMBL17338927 | 0.68 | MAPT (0.62) | SCN7AKCNH2KMT2AHTTFKBP1A | |
| SCHEMBL29222005 | 0.67 | SLC6A9 (0.53) | FASNRORCKMT2AHTTHPGD | |
| SCHEMBL3457210 | 0.67 | CYP11B2 (0.37) | EGLN1KCNH2HRH2HRH1 | |
| SCHEMBL6359772 | 0.64 | NAMPT (0.42) | ALKHRH2HRH1ADAM10MMP2 | |
| SCHEMBL19049602 | 0.63 | FKBP1A (0.67) | KMT2AFKBP1ASMN1; SMN2NPC1 | |
| SCHEMBL5321408 | 0.63 | HTR6 (0.59) | ALKKMT2ACYP1A2CYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264030-A1 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | Incyte Corporation (US) | 2010-12-22 | — | — | EP | disclosed |