Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | FURIN | P09958 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7265757 | 0.85 | LTA4H (0.50) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6290722 | 0.80 | SMN1; SMN2 (0.60) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6290436 | 0.80 | SMN1; SMN2 (0.60) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6290665 | 0.80 | SMN1; SMN2 (0.60) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6289859 | 0.80 | SMN1; SMN2 (0.60) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL4569951 | 0.80 | SMN1; SMN2 (0.60) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6289255 | 0.80 | SMN1; SMN2 (0.60) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7940811 | 0.77 | ALDH1A1 (0.50) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL27443501 | 0.76 | MAPT (0.50) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2394719 | 0.76 | MAOB (0.59) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264036-A1 | Amino-imidazolones for the inhibition of beta-secretase | Wyeth LLC (Formerly Known As Wyeth) (US) | 2010-12-22 | — | — | EP | disclosed |
| US-20090253716-A1 | AMINO-IMIDAZOLONES FOR THE INHIBITION OF BETA-SECRETASE | WYETH (US) | 2009-10-08 | — | — | US | disclosed |
| US-7563796-B2 | Diphenylimidazopyrimidines as inhibitors of β-secretase | WYETH (US) | 2009-07-21 | — | — | US | disclosed |
| EP-1836208-A2 | AMINO-IMIDAZOLONES FOR THE INHIBITION OF ß-SECRETASE | Wyeth Incoporated (US) | 2007-09-26 | — | — | EP | disclosed |
| US-20060160828-A1 | Amino-imidazolones for the inhibition of beta-secretase | WYETH (US) | 2006-07-20 | — | — | US | disclosed |
| WO-2006076284-A2 | AMINO-IMIDAZOLONES FOR THE INHIBITION OF ß-SECRETASE | WYETH (US) | 2006-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160828-A1 | Amino-imidazolones for the inhibition of beta-secretase | BACE1, BACE2, APP | ALDH1A1 2917/4885MAPT 13/4885SMN1; SMN2 1408/4885 |
| US-20090253716-A1 | AMINO-IMIDAZOLONES FOR THE INHIBITION OF BETA-SECRETASE | BACE1, BACE2, APP | ALDH1A1 2917/4885MAPT 13/4885SMN1; SMN2 1408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.