Choline

Choline

SCHEMBL7738255

C[N+](C)(C)CCO.NC(=O)[O-]

nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2

The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.60
MEN1 O00255 1/20 0.60
KMT2A Q03164 1/20 0.60
CYP3A4 P08684 1/20 0.60
SLC5A7 Q9GZV3 1/20 0.60
CHRM5 P08912 4/20 0.44
CHRM1 P11229 4/20 0.44
CHRM3 P20309 4/20 0.44
CHRM2 P08172 3/20 0.44
CHRM4 P08173 3/20 0.44
HTR1A P08908 2/20 0.44
CHRNB2 P17787 2/20 0.44
CYP2C19 P33261 2/20 0.44
CHRNA7 P36544 2/20 0.44
CHRNA4 P43681 2/20 0.44
TSHR P16473 1/20 0.44
GALR3 O60755 2/20 0.40
ACHE P22303 1/20 0.37
CPT2 P23786 1/20 0.37
CPT1A P50416 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Choline SCHEMBL3458979 0.97 LMNA (0.57) LMNAMEN1KMT2ACYP3A4SLC5A7
Choline SCHEMBL3458973 0.97 CYP3A4 (0.65) LMNAMEN1KMT2ACYP3A4SLC5A7
Choline SCHEMBL20358854 0.90 LMNA (0.55) LMNAMEN1KMT2ACYP3A4SLC5A7
Choline SCHEMBL23355962 0.89 LMNA (0.67) LMNAMEN1KMT2ACYP3A4SLC5A7
Choline SCHEMBL119824 0.89 LMNA (0.67) LMNAMEN1KMT2ACYP3A4SLC5A7
Choline SCHEMBL15993952 0.88 CYP3A4 (0.59) LMNAMEN1KMT2ACYP3A4SLC5A7
Choline SCHEMBL2222247 0.86 LMNA (0.63) LMNAMEN1KMT2ACYP3A4SLC5A7
Choline SCHEMBL516453 0.86 CYP3A4 (0.72) LMNAMEN1KMT2ACYP3A4SLC5A7
Choline SCHEMBL316506 0.86 LMNA (0.63) LMNAMEN1KMT2ACYP3A4SLC5A7
Choline SCHEMBL15993853 0.86 LMNA (0.63) LMNAMEN1KMT2ACYP3A4SLC5A7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117039207-B Battery, iodine electrode material and preparation method of electrolyte 广东工业大学 2024-07-30 CN claimed
CN-117039207-A Battery, iodine electrode material and preparation method of electrolyte 广东工业大学 2023-11-10 CN claimed
US-20260085166-A1 BACTERIAL CELLULOSE GELS, PROCESS FOR PRODUCING AND METHODS FOR USE THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) 2026-03-26 US disclosed
US-12486376-B2 Bacterial cellulose gels, process for producing and methods for use THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) 2025-12-02 US disclosed
US-20250122350-A1 CELLULOSE-ENABLED ORIENTATIONALLY ORDERED FLEXIBLE GELS UNIV COLORADO REGENTS (US) 2025-04-17 US disclosed
US-12129353-B2 Cellulose-enabled orientationally ordered flexible gels THE REGENTS OF THE UNIVERSITY OF COLORADO (US) 2024-10-29 US disclosed
CN-117039207-B Battery, iodine electrode material and preparation method of electrolyte 广东工业大学 2024-07-30 CN disclosed
US-20240158601-A1 BACTERIAL CELLULOSE GELS, PROCESS FOR PRODUCING AND METHODS FOR USE US DEPARTMENT OF ENERGY 2024-05-16 US disclosed
CN-117039207-A Battery, iodine electrode material and preparation method of electrolyte 广东工业大学 2023-11-10 CN disclosed
US-20220168325-A1 METHODS TO PROMOTE CEREBRAL BLOOD FLOW IN THE BRAIN THE UNIVERSITY OF VERMONT 2022-06-02 US disclosed
US-11344534-B2 Cholinergic agonism for the treatment of pancreatic cancer THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2022-05-31 US disclosed
WO-2019005874-A1 CHOLINERGIC AGONISM FOR THE TREATMENT OF PANCREATIC CANCER THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2019-01-03 WO disclosed
US-20180237608-A1 CELLULOS-ENABLED ORIENTATIONALLY ORDERED FLEXIBLE GELS THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE 2018-08-23 US disclosed
WO-2018089204-A2 COMBINATION THERAPIES FOR TREATING BIPOLAR DISORDER, AND METHODS FOR USING THE SAME PSYCHNOSTICS, LLC (US) 2018-05-17 WO disclosed
US-6414033-B1 DETERMINATION PH; BUFFER SOLUTION GELSUS RESEARCH AND CONSULTING, INC. 2002-07-02 US disclosed
EP-1049424-A4 A DRUG DOSAGE FORM BASED ON THE TEORELL-MEYER GRADIENT SCEUSA NICHOLAS A (US) 2001-11-28 EP disclosed
EP-1049424-A1 A DRUG DOSAGE FORM BASED ON THE TEORELL-MEYER GRADIENT Sceusa, Nicholas A. (US) 2000-11-08 EP disclosed
WO-1999034751-A1 A DRUG DOSAGE FORM BASED ON THE TEORELL-MEYER GRADIENT SCEUSA NICHOLAS A (US) 1999-07-15 WO disclosed
US-5607691-A IONTOPHORESIS AFFYMAX TECHNOLOGIES N.V. (GB) 1997-03-04 US disclosed
CN-85109716-A Preparation octahydro indoles is (2,3-α) quinolizine-1-base-alkane hydroxy acid acid amides and acid salt thereof and the method that contains their pharmaceutical composition also 1986-10-08 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11344534-B2 Cholinergic agonism for the treatment of pancreatic cancer CHRM3, CHRNA1, CHRNA3 LMNA 4467/4885MEN1 637/4885KMT2A 993/4885
US-20260085166-A1 BACTERIAL CELLULOSE GELS, PROCESS FOR PRODUCING AND METHODS FOR USE LRBA, VCL, ILK LMNA 1307/4885MEN1 3087/4885KMT2A 3547/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.