Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MPI | P34949 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11494596 | 0.86 | ITGB3 (0.42) | SMN1; SMN2KMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL22878181 | 0.77 | ATM (0.45) | GLASMN1; SMN2KMT2AALDH1A1MEN1 | |
| SCHEMBL15362709 | 0.77 | ALDH1A1 (0.61) | SMN1; SMN2KMT2AALDH1A1MEN1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL17271473 | 0.76 | ALDH1A1 (0.45) | GLASMN1; SMN2KMT2AALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL15352721 | 0.76 | ALDH1A1 (0.60) | SMN1; SMN2KMT2AALDH1A1MEN1L3MBTL1 | |
| SCHEMBL3021250 | 0.75 | LMNA (0.56) | SMN1; SMN2KMT2AALDH1A1MEN1LMNA | |
| SCHEMBL7130431 | 0.74 | GLA (0.46) | GLASMN1; SMN2KMT2AALDH1A1MAPT | |
| SCHEMBL2146806 | 0.72 | ALDH1A1 (0.55) | SMN1; SMN2KMT2AALDH1A1MEN1L3MBTL1 | |
| SCHEMBL2146803 | 0.72 | ALDH1A1 (0.55) | SMN1; SMN2KMT2AALDH1A1MEN1L3MBTL1 | |
| SCHEMBL3557649 | 0.72 | GLA (0.44) | GLASMN1; SMN2KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240447-A2 | MORPHOLINE DERIVATES AS ANTIOBESITY AGENTS | AstraZeneca AB (Publ) (SE) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009071678-A2 | MORPHOLINE DERIVATIVES AS ANTIOBESITY AGENTS | BIOVITRUM AB (PUBL) (SE) | 2009-06-11 | — | — | WO | disclosed |