Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.46 |
| ▸ | GPR52 | Q9Y2T5 | 3/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1500536 | 0.82 | TSHR (0.51) | MAPK8RPS6KB1AURKALMNAHTT | |
| SCHEMBL3462285 | 0.81 | MAPK8 (0.48) | MAPK8GPR52RPS6KB1AURKAKDM4E | |
| SCHEMBL28177161 | 0.79 | TBXA2R (0.54) | LMNATSHRKDM4EALDH1A1 | |
| SCHEMBL3461077 | 0.79 | TSHR (0.51) | MAPK8LMNATSHRKDM4EALDH1A1 | |
| SCHEMBL3461564 | 0.78 | MAPK8 (0.49) | MAPK8RPS6KB1AURKALMNAHTT | |
| SCHEMBL3461101 | 0.78 | ADRA1D (0.49) | MAPK8GPR52LMNAKDM4EALDH1A1 | |
| SCHEMBL3461063 | 0.78 | TBXA2R (0.55) | RPS6KB1AURKALMNATSHRKDM4E | |
| SCHEMBL1004028 | 0.78 | TSHR (0.58) | TSHRKDM4EALDH1A1CA1CA2 | |
| SCHEMBL7134588 | 0.77 | TSHR (0.54) | TSHRKDM4EALDH1A1PARP1 | |
| SCHEMBL5723934 | 0.77 | KEAP1 (0.56) | RPS6KB1AURKATSHRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7704995-B2 | Protein kinase modulators and methods of use | EXELIXIS, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-20060211709-A1 | Protein kinase modulators and methods of use | EXELIXIS, INC. | 2006-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211709-A1 | Protein kinase modulators and methods of use | GRK2, MAP4K2, MAPKAPK2 | MAPK8 224/4885GPR52 643/4885RPS6KB1 180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.