Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CLPP | Q16740 | 1/20 | 0.35 |
| ▸ | GUSB | P08236 | 2/20 | 0.35 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.35 |
| ▸ | BRS3 | P32247 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3455866 | 0.85 | DRD2 (0.44) | MEN1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL3455104 | 0.85 | MEN1 (0.47) | MEN1KMT2AAMY1ACLPPGUSB | |
| SCHEMBL3455882 | 0.84 | DRD2 (0.47) | AMY1AALDH1A1CLPPGUSBAURKA | |
| SCHEMBL13070128 | 0.81 | DRD2 (0.38) | MEN1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL3455100 | 0.81 | BRD4 (0.38) | MEN1KMT2AAMY1AKDM4EALDH1A1 | |
| SCHEMBL3455305 | 0.80 | ALDH1A1 (0.44) | MEN1KMT2AKDM4EALDH1A1GUSB | |
| SCHEMBL3455636 | 0.80 | ALDH1A1 (0.38) | MEN1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL3455272 | 0.80 | HTR6 (0.43) | MEN1KMT2AAMY1APTPN11TRPV1 | |
| SCHEMBL3456801 | 0.79 | KIT (0.41) | CLPPGUSBDRD2 | |
| SCHEMBL3457104 | 0.79 | P2RX7 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251340-A1 | Substituted tetrahydro-1h-pyrazolo[3,4-c] pyridines, compositions containing same and use thereof | Aventis Pharma S.A. (FR) | 2010-11-17 | — | — | EP | disclosed |
| US-7435820-B2 | Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use | AVENTIS PHARMA S.A. (FR) | 2008-10-14 | — | — | US | disclosed |
| US-7435820-B2 | Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use | AVENTIS PHARMA S.A. (FR) | 2008-10-14 | — | — | US | disclosed |