Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDX3X | O00571 | 2/20 | 0.70 |
| ▸ | RAB9A | P51151 | 8/20 | 0.66 |
| ▸ | NPC1 | O15118 | 6/20 | 0.66 |
| ▸ | MAPT | P10636 | 5/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | KDR | P35968 | 3/20 | 0.54 |
| ▸ | GHSR | Q92847 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5852186 | 0.86 | DDX3X (0.70) | DDX3XRAB9ANPC1MAPTKMT2A | |
| SCHEMBL812756 | 0.86 | DDX3X (0.80) | DDX3XRAB9ANPC1MAPTKMT2A | |
| SCHEMBL3460448 | 0.84 | RAB9A (0.71) | DDX3XRAB9ANPC1MAPTKMT2A | |
| SCHEMBL16942599 | 0.84 | RAB9A (0.62) | DDX3XRAB9ANPC1MAPTKMT2A | |
| SCHEMBL1275926 | 0.84 | RAB9A (0.75) | DDX3XRAB9ANPC1MAPTKMT2A | |
| SCHEMBL17079606 | 0.83 | RAB9A (0.66) | DDX3XRAB9ANPC1MAPTKMT2A | |
| SCHEMBL687547 | 0.83 | RAB9A (0.66) | DDX3XRAB9ANPC1MAPTKMT2A | |
| SCHEMBL17084259 | 0.83 | RAB9A (0.67) | DDX3XRAB9ANPC1MAPTKMT2A | |
| SCHEMBL3460675 | 0.83 | DDX3X (0.69) | DDX3XRAB9ANPC1MAPTKMT2A | |
| SCHEMBL5683215 | 0.83 | DDX3X (0.65) | DDX3XRAB9ANPC1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108794408-B | Pyrimidine phenylurea anti-tumor compound and preparation method and application thereof | 中国医科大学 | 2020-04-21 | — | — | CN | disclosed |
| EP-3432881-A1 | USE OF DDX3 INHIBITORS AS ANTIPROLIFERATIVE AGENTS | Azienda Ospedaliera Universitaria Senese (IT) | 2019-01-30 | — | — | EP | disclosed |
| CN-109069484-A | Purposes of the DDX3 inhibitor as antiproliferative | 锡耶纳大学医院 | 2018-12-21 | — | — | CN | disclosed |
| CN-108794408-A | Pyrimidine phenylurea anti-tumor compounds and its preparation method and application | 中国医科大学 | 2018-11-13 | — | — | CN | disclosed |
| EP-3256461-A1 | HUMAN HELICASE DDX3 INHIBITORS AS THERAPEUTIC AGENTS | Azienda Ospedaliera Universitaria Senese (IT) | 2017-12-20 | — | — | EP | disclosed |
| WO-2017162834-A1 | USE OF DDX3 INHIBITORS AS ANTIPROLIFERATIVE AGENTS | AZIENDA OSPEDALIERA UNIVERSITARIA SENESE (IT) | 2017-09-28 | — | — | WO | disclosed |
| WO-2017162834-A1 | USE OF DDX3 INHIBITORS AS ANTIPROLIFERATIVE AGENTS | AZIENDA OSPEDALIERA UNIVERSITARIA SENESE (IT) | 2017-09-28 | — | — | WO | disclosed |
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |
| WO-2016128541-A1 | HUMAN HELICASE DDX3 INHIBITORS AS THERAPEUTIC AGENTS | AZIENDA OSPEDALIERA UNIVERSITARIA SENESE (IT) | 2016-08-18 | — | — | WO | disclosed |
| EP-1406865-A2 | SUCCINIC ACID DERIVATIVES | Bayer HealthCare AG (DE) | 2004-04-14 | — | — | EP | disclosed |
| US-20040058904-A1 | Beta-amino acid derivatives as integrin receptor antagonists | BAYER AKTIENGESELLSCHAFT (DE) | 2004-03-25 | — | — | US | disclosed |
| EP-1326828-A1 | BETA-AMINO ACID DERIVATIVES AS INTEGRIN RECEPTOR ANTAGONISTS | Bayer Aktiengesellschaft (DE) | 2003-07-16 | — | — | EP | disclosed |
| WO-2003004460-A2 | SUCCINIC ACID DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2003-01-16 | — | — | WO | disclosed |
| WO-2003004460-A2 | SUCCINIC ACID DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2003-01-16 | — | — | WO | disclosed |
| WO-2002030874-A2 | ALIPHATIC, CYCLIC AMINO CARBOXYLIC ACIDS AS INTEGRIN ANTAGONISTS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-04-18 | — | — | WO | disclosed |
| WO-2002030875-A1 | BETA-AMINO ACID DERIVATIVES AS INTEGRIN RECEPTOR ANTAGONISTS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-04-18 | — | — | WO | disclosed |
| WO-2002030876-A2 | CYCLIC CARBOXYLIC ACIDS AS INTEGRIN ANTAGONISTS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-04-18 | — | — | WO | disclosed |
| EP-1173415-A1 | DIPHENYLUREA DERIVATIVES | AstraZeneca AB (SE) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000064866-A1 | DIPHENYLUREA DERIVATIVES | ASTRAZENECA AB (SE) | 2000-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058904-A1 | Beta-amino acid derivatives as integrin receptor antagonists | ITGAL, ITGB1, ITGB2 | DDX3X 4861/4885RAB9A 1080/4885NPC1 3652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.