Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | KDM1A | O60341 | 3/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1639437 | 0.81 | KDM4E (0.65) | KDM4ETLR8ALDH1A1MAPTCYP1A2 | |
| SCHEMBL28249502 | 0.81 | TLR8 (0.57) | KDM4ETSHRTLR8 | |
| SCHEMBL1641167 | 0.78 | KDM4E (1.00) | KDM4ETLR8LMNAALDH1A1MAPT | |
| SCHEMBL30315534 | 0.78 | KDM4E (1.00) | KDM4ETLR8LMNAALDH1A1MAPT | |
| SCHEMBL9189248 | 0.78 | KDM4E (0.51) | KDM4ETLR8LMNAMAPTKMT2A | |
| SCHEMBL27696506 | 0.76 | MAPT (0.59) | KDM4ETSHRKDM1AMPOTLR8 | |
| SCHEMBL13134303 | 0.74 | THRB (0.54) | KDM4ETSHRALDH1A1MEN1KMT2A | |
| SCHEMBL8560716 | 0.73 | TSHR (0.49) | KDM4ETSHRKDM1AALDH1A1MAPT | |
| SCHEMBL28293113 | 0.72 | TSHR (0.59) | KDM4ETSHRKDM1ATLR8LMNA | |
| Hydrochloric Acid SCHEMBL28059935 | 0.72 | NCF1 (0.49) | KDM4ETSHRMPOALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723337-B2 | 3-cinnolinecarboxamide derivatives and their use for treating cancer | ASTRAZENECA AB (SE) | 2010-05-25 | — | — | US | disclosed |
| US-20090012084-A1 | 3-CINNOLINECARBOXAMIDE DERIVATIVES AND THEIR USE FOR TREATING CANCER | ASTRAZENECA AB (SE) | 2009-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012084-A1 | 3-CINNOLINECARBOXAMIDE DERIVATIVES AND THEIR USE FOR TREATING CANCER | CSF3R, CSF1R, KIT | KDM4E 2188/4885TSHR 3316/4885KDM1A 1134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.