⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22966410 | 0.79 | CES2 (0.39) | — | |
| SCHEMBL2933753 | 0.79 | HTR1A (0.32) | — | |
| SCHEMBL12092363 | 0.78 | CES2 (0.32) | — | |
| SCHEMBL2223767 | 0.77 | — | — | |
| SCHEMBL10952646 | 0.74 | — | — | |
| SCHEMBL20173442 | 0.74 | — | — | |
| SCHEMBL11438338 | 0.74 | PTGES (0.35) | — | |
| SCHEMBL3085260 | 0.74 | — | — | |
| SCHEMBL10364270 | 0.74 | — | — | |
| SCHEMBL13698346 | 0.72 | TDP1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9486422-B2 | Small molecule inhibitors of Mcl-1 and the uses of thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-11-08 | — | — | US | disclosed |
| US-8975247-B2 | Methods and compositions of treating a flaviviridae family viral infection | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNION UNIVERSITY (US) | 2015-03-10 | — | — | US | disclosed |
| US-8846855-B2 | Conjugated fused thiophenes, methods of making conjugated fused thiophenes, and uses thereof | CORNING INCORPORATED (US) | 2014-09-30 | — | — | US | disclosed |
| US-20140235702-A1 | SMALL MOLECULE INHIBITORS OF MCL-1 AND THE USES OF THEREOF | WAYNE STATE UNIVERSITY | 2014-08-21 | — | — | US | disclosed |
| US-20130109821-A1 | CONJUGATED FUSED THIOPHENES, METHODS OF MAKING CONJUGATED FUSED THIOPHENES, AND USES THEREOF | CORNING INCORPORATED | 2013-05-02 | — | — | US | disclosed |
| US-20130085256-A1 | FUSED THIOPHENES, METHODS OF MAKING FUSED THIOPHENES, AND USES THEREOF | CORNING INCORPORATED | 2013-04-04 | — | — | US | disclosed |
| US-8389669-B2 | Fused thiophenes, methods for making fused thiophenes, and uses thereof | CORNING INCORPORATED (US) | 2013-03-05 | — | — | US | disclosed |
| US-8349998-B2 | Fused thiophenes, methods for making fused thiophenes, and uses thereof | CORNING INCORPORATED (US) | 2013-01-08 | — | — | US | disclosed |
| US-20120276050-A1 | METHODS AND COMPOSITIONS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-11-01 | — | — | US | disclosed |
| US-20110082278-A1 | FUSED THIOPHENES, METHODS FOR MAKING FUSED THIOPHENES, AND USES THEREOF | HE MINGQIAN | 2011-04-07 | — | — | US | disclosed |
| US-20070225285-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | AMIRA PHARMACEUTICALS, INC. (US) | 2007-09-27 | — | — | US | disclosed |
| US-20070225285-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | AMIRA PHARMACEUTICALS, INC. (US) | 2007-09-27 | — | — | US | disclosed |
| US-20070225285-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | AMIRA PHARMACEUTICALS, INC. (US) | 2007-09-27 | — | — | US | disclosed |
| US-20070219206-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | AMIRA PHARMACEUTICALS, INC. (US) | 2007-09-20 | — | — | US | disclosed |
| US-20070219206-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | AMIRA PHARMACEUTICALS, INC. (US) | 2007-09-20 | — | — | US | disclosed |
| US-20070219206-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | AMIRA PHARMACEUTICALS, INC. (US) | 2007-09-20 | — | — | US | disclosed |
| US-20070161776-A1 | Fused thiophenes, methods for making fused thiophenes, and uses thereof | CORNING INCORPORATED | 2007-07-12 | — | — | US | disclosed |
| US-5550276-A | OIL ADDITIVES | CIBA-GEIGY CORPORATION (US) | 1996-08-27 | — | — | US | disclosed |
| EP-0438375-B1 | Phosphonic acids and thiophosphonic acid derivatives | CIBA GEIGY AG (CH) | 1995-12-27 | — | — | EP | disclosed |
| EP-0438375-A2 | Phosphonic acids and thiophosphonic acid derivatives | CIBA-GEIGY AG (CH) | 1991-07-24 | — | — | EP | disclosed |