Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.86 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.48 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.48 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.48 |
| ▸ | NAAA | Q02083 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL3464394 | 1.00 | TSHR (0.86) | TSHRTHRBLPAR3LPAR1LPAR2 | |
| Phosphoric Acid SCHEMBL27578854 | 0.93 | TSHR (0.72) | TSHRTHRBLPAR3LPAR1LPAR2 | |
| SCHEMBL6655183 | 0.93 | TSHR (1.00) | TSHRTHRBNAAAPOLBAPEX1 | |
| SCHEMBL14995 | 0.93 | TSHR (1.00) | TSHRTHRBNAAAPOLBAPEX1 | |
| SCHEMBL7769529 | 0.93 | TSHR (1.00) | TSHRTHRBNAAAPOLBAPEX1 | |
| SCHEMBL11775454 | 0.93 | TSHR (1.00) | TSHRTHRBNAAAPOLBAPEX1 | |
| SCHEMBL1977194 | 0.93 | TSHR (1.00) | TSHRTHRBNAAAPOLBAPEX1 | |
| SCHEMBL15200 | 0.93 | TSHR (1.00) | TSHRTHRBNAAAPOLBAPEX1 | |
| SCHEMBL21853811 | 0.93 | TSHR (1.00) | TSHRTHRBNAAAPOLBAPEX1 | |
| SCHEMBL22579031 | 0.93 | TSHR (1.00) | TSHRTHRBNAAAPOLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10478384-B2 | Dental composition | ZIMMER DENTAL, INC. (US) | 2019-11-19 | — | — | US | claimed |
| US-20140161901-A1 | DENTAL COMPOSITION | ZIMMER DENTAL, INC. (US) | 2014-06-12 | — | — | US | claimed |
| US-8211956-B2 | Universal dental adhesion-promoter composition | IVOCLAR VIVADENT AG (LI) | 2012-07-03 | — | — | US | claimed |
| US-10478384-B2 | Dental composition | ZIMMER DENTAL, INC. (US) | 2019-11-19 | — | — | US | disclosed |
| US-9974716-B2 | Dental primer formulation | IVOCLAR VIVADENT AG (LI) | 2018-05-22 | — | — | US | disclosed |
| US-20160022549-A1 | DENTAL PRIMER FORMULATION | IVOCLAR VIVADENT AG (LI) | 2016-01-28 | — | — | US | disclosed |
| US-20140161901-A1 | DENTAL COMPOSITION | ZIMMER DENTAL, INC. (US) | 2014-06-12 | — | — | US | disclosed |
| US-8211956-B2 | Universal dental adhesion-promoter composition | IVOCLAR VIVADENT AG (LI) | 2012-07-03 | — | — | US | disclosed |
| US-20100240796-A1 | UNIVERSAL DENTAL ADHESION-PROMOTER COMPOSITION | IVOCLAR VIVADENT AG (LI) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10478384-B2 | Dental composition | CAD, PPIP5K2, PTH1R | TSHR 3937/4885THRB 1732/4885LPAR3 2504/4885 |
| US-20160022549-A1 | DENTAL PRIMER FORMULATION | F12, H1-2, H1-0 | TSHR 746/4885THRB 1805/4885LPAR3 962/4885 |
| US-20140161901-A1 | DENTAL COMPOSITION | CAD, PPIP5K2, PTH1R | TSHR 3937/4885THRB 1732/4885LPAR3 2504/4885 |
| US-20100240796-A1 | UNIVERSAL DENTAL ADHESION-PROMOTER COMPOSITION | CDH1, CAD, CD44 | TSHR 4027/4885THRB 2263/4885LPAR3 3081/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.