Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.77 |
| ▸ | RAB9A | P51151 | 3/20 | 0.77 |
| ▸ | RECQL | P46063 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1340160 | 0.95 | NPC1 (0.74) | NPC1RAB9ARECQLALDH1A1KMT2A | |
| SCHEMBL31734218 | 0.93 | NPC1 (0.72) | NPC1RAB9ARECQLALDH1A1KMT2A | |
| SCHEMBL50769 | 0.93 | NPC1 (0.72) | NPC1RAB9ARECQLALDH1A1KMT2A | |
| SCHEMBL29361974 | 0.93 | NPC1 (0.72) | NPC1RAB9ARECQLALDH1A1KMT2A | |
| SCHEMBL2304857 | 0.93 | NPC1 (0.72) | NPC1RAB9ARECQLALDH1A1KMT2A | |
| SCHEMBL8581954 | 0.93 | NPC1 (0.72) | NPC1RAB9ARECQLALDH1A1KMT2A | |
| SCHEMBL18012379 | 0.93 | NPC1 (0.72) | NPC1RAB9ARECQLALDH1A1KMT2A | |
| SCHEMBL1123538 | 0.93 | NPC1 (0.72) | NPC1RAB9ARECQLALDH1A1KMT2A | |
| SCHEMBL30517741 | 0.93 | NPC1 (0.72) | NPC1RAB9ARECQLALDH1A1KMT2A | |
| SCHEMBL29794119 | 0.93 | NPC1 (0.72) | NPC1RAB9ARECQLALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100224030-A1 | INDIUM RECOVERY BY SUPPORTED LIQUID MEMBRANE WITH STRIP DISPERSION | CHUNG YUAN CHRISTIAN UNIVERSITY (TW) | 2010-09-09 | — | — | US | claimed |
| US-6433163-B1 | EXTRACTION, SEPARATION | COMMODORE SEPARATION TECHNOLIGIES, INC. | 2002-08-13 | — | — | US | claimed |
| US-6350419-B1 | SUPPORTED LIQUID MEMBRANE/ STRIP DISPERSION FOR REMOVAL OF METALS | COMMODORE SEPARATION TECHNOLOGIES INC. | 2002-02-26 | — | — | US | claimed |
| US-6328782-B1 | TREATING FEED SOLUTION CONTAINING RADIONUCLIDES OR METALS BY PASSING FEED SOLUTION ON ONE SIDE OF SUPPORTED LIQUID MEMBRANE EMBEDDED IN MICROPOROUS SUPPORT AND REMOVING RADIONUCLIDES BY USE OF STRIP DISPERSION ON OTHER SIDE OF MEMBRANE; SEPARATION | COMMODORE SEPARATION TECHNOLOGIES, INC. | 2001-12-11 | — | — | US | claimed |
| US-20010029810-A1 | Alkyl phenylphosphonic acid extractants and processes for their manufacture | HO W S WINSTON (US) | 2001-10-18 | — | — | US | claimed |
| WO-2001056933-A2 | COMBINED SUPPORTED LIQUID MEMBRANE/STRIP DISPERSION PROCESSES AND EXTRACTANTS | COMMODORE SEPARATION TECHNOLOGIES, INC. (US) | 2001-08-09 | — | — | WO | claimed |
| US-6171563-B1 | Supported liquid membrane process for chromium removal and recovery | COMMODORE SEPARATION TECHNOLOGIES, INC. | 2001-01-09 | — | — | US | claimed |
| EP-2847174-B1 | PYRIMIDINONE CARBOXAMIDES AS INHIBITORS OF ENDOTHELIAL LIPASE | BRISTOL MYERS SQUIBB CO (US) | 2017-05-17 | — | — | EP | disclosed |
| US-9394260-B2 | Pyrimidinone carboxamide inhibitors of endothelial lipase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-07-19 | — | — | US | disclosed |
| US-20150361052-A1 | PYRIMIDINONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE | BRISTOL-MYERS SQUIBB COMPANY | 2015-12-17 | — | — | US | disclosed |
| EP-2723478-B1 | PERTRACTION PROCESS | TNO (NL) | 2015-07-29 | — | — | EP | disclosed |
| EP-2723478-A1 | PERTRACTION PROCESS | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO (NL) | 2014-04-30 | — | — | EP | disclosed |
| WO-2013151923-A1 | PYRIMIDINONE CARBOXAMIDES AS INHIBITORS OF ENDOTHELIAL LIPASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-10-10 | — | — | WO | disclosed |
| US-4780411-A | HYDROPHOBIC FILM FORMING WATER INSOLUBLE POLYMER CONTAINING HYDROPHILIC PARTICLES | BAYER AKTIENGESELLSCHAFT (DE) | 1988-10-25 | — | — | US | disclosed |
| US-4670218-A | HOMOGENEOUS HYDROPHOBIC SUBSTANCE, IONOPHORE CAPABLE OF COMPL EXING WITH THE ION REPORTER SUBSTANCE | MILES LABORATORIES, INC. (US) | 1987-06-02 | — | — | US | disclosed |
| US-4649123-A | CLINICAL DETERMINATIONS OF SERUM POTASSIUM | MILES LABORATORIES, INC. (US) | 1987-03-10 | — | — | US | disclosed |
| US-4645744-A | FORMING COMPLEX WITH IONOPHORE ON CARRIER MATRIX | MILES LABORATORIES, INC. (US) | 1987-02-24 | — | — | US | disclosed |
| EP-0196025-A2 | Process for the preparation of 4,4'-diaminodiphenyl compounds, and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-10-01 | — | — | EP | disclosed |
| EP-0153641-A2 | Ion test means having a porous carrier matrix | MILES INC. (US) | 1985-09-04 | — | — | EP | disclosed |
| US-4076849-A | AROMATIC SECONDARY AMINES | CANADA PACKERS LIMITED (CA) | 1978-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150361052-A1 | PYRIMIDINONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE | LIPG, LPL, PNLIP | NPC1 1777/4885RAB9A 3958/4885RECQL 1528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.