Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL28744937 | 0.86 | NAPRT (0.58) | NAPRTRAB9ASMN1; SMN2GRM4L3MBTL1 | |
| SCHEMBL28744934 | 0.82 | NAPRT (0.49) | NAPRTRAB9ASMN1; SMN2GRM4L3MBTL1 | |
| SCHEMBL1877325 | 0.81 | NAPRT (0.60) | NAPRTRAB9ASMN1; SMN2GRM4L3MBTL1 | |
| SCHEMBL30175321 | 0.81 | NAPRT (0.60) | NAPRTRAB9ASMN1; SMN2GRM4L3MBTL1 | |
| SCHEMBL6389786 | 0.81 | NAPRT (0.60) | NAPRTRAB9ASMN1; SMN2GRM4L3MBTL1 | |
| SCHEMBL1985578 | 0.81 | NAPRT (0.64) | NAPRTRAB9ASMN1; SMN2GRM4L3MBTL1 | |
| SCHEMBL10812902 | 0.80 | HDAC1 (0.58) | RAB9ASMN1; SMN2MAPTKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL9753763 | 0.80 | NAPRT (0.58) | NAPRTRAB9ASMN1; SMN2GRM4L3MBTL1 | |
| Hydrochloric Acid SCHEMBL12098974 | 0.80 | NAPRT (0.58) | NAPRTRAB9ASMN1; SMN2GRM4L3MBTL1 | |
| SCHEMBL6439911 | 0.79 | NAPRT (0.62) | NAPRTRAB9ASMN1; SMN2GRM4L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8742118-B2 | Methods for preparing intermediates of perampanel | F.I.S.—Fabbrica Italiana Sintetici S.p.A. (IT) | 2014-06-03 | — | — | US | disclosed |
| US-20130109862-A1 | METHODS FOR PREPARING INTERMEDIATES OF PERAMPANEL | F.I.S. FABRICA ITALIANA SINTETICI S.p.A. (IT) | 2013-05-02 | — | — | US | disclosed |
| US-8324216-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100240618-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2010-09-23 | — | — | US | disclosed |
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-20060106218-A1 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2006-05-18 | — | — | US | disclosed |
| US-20050256130-A1 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106218-A1 | Substituted piperazines | CCR1, CCR3, CCRL2 | NAPRT 1662/4885RAB9A 4163/4885SMN1; SMN2 1026/4885 |
| US-20050256130-A1 | Substituted piperazines | CCR1, CCR3, CCRL2 | NAPRT 1662/4885RAB9A 4163/4885SMN1; SMN2 1026/4885 |
| US-20130109862-A1 | METHODS FOR PREPARING INTERMEDIATES OF PERAMPANEL | PDXK, AGPS, PNPO | NAPRT 171/4885RAB9A 2788/4885SMN1; SMN2 1561/4885 |
| US-20100240618-A1 | SUBSTITUTED PIPERAZINES | CCR1, CCR3, CCRL2 | NAPRT 1662/4885RAB9A 4163/4885SMN1; SMN2 1026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.