Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | HTR1D | P28221 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | FAAH | O00519 | 12/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL346170 | 0.95 | DRD2 (0.57) | DRD2HTR1DDRD3FAAHCA1 | |
| SCHEMBL12472925 | 0.90 | DRD2 (0.50) | DRD2HTR1DDRD3FAAHPKM | |
| SCHEMBL6749712 | 0.87 | DRD2 (0.50) | DRD2HTR1DDRD3FAAH | |
| SCHEMBL6936763 | 0.87 | DRD2 (0.52) | DRD2HTR1DDRD3FAAHPKM | |
| SCHEMBL8603697 | 0.83 | CA1 (0.59) | DRD2DRD3FAAHCA1CA2 | |
| SCHEMBL8076218 | 0.83 | CA1 (0.59) | DRD2DRD3FAAHCA1CA2 | |
| SCHEMBL8066286 | 0.83 | CA1 (0.59) | DRD2DRD3FAAHCA1CA2 | |
| SCHEMBL10197905 | 0.81 | MTNR1A (0.48) | DRD2HTR1DDRD3FAAHCA1 | |
| SCHEMBL17067891 | 0.80 | FAAH (0.69) | FAAH | |
| SCHEMBL7280750 | 0.80 | FAAH (0.48) | FAAHCA1CA2ACHEPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9504675-B2 | Alpha-ketoheterocycles and methods of making and using | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-11-29 | — | — | US | disclosed |
| US-9504675-B2 | Alpha-ketoheterocycles and methods of making and using | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-11-29 | — | — | US | disclosed |
| US-9504675-B2 | Alpha-ketoheterocycles and methods of making and using | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-11-29 | — | — | US | disclosed |
| EP-2670245-B1 | ALPHA-KETOHETEROCYCLES AND METHODS OF MAKING AND USING | SCRIPPS RESEARCH INST (US) | 2015-09-09 | — | — | EP | disclosed |
| US-20140243334-A1 | SUBSTITUTED HYDOXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-08-28 | — | — | US | disclosed |
| US-20130338196-A1 | ALPHA-KETOHETEROCYCLES AND METHODS OF MAKING AND USING | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-12-19 | — | — | US | disclosed |
| EP-2670245-A1 | ALPHA-KETOHETEROCYCLES AND METHODS OF MAKING AND USING | The Scripps Research Institute (US) | 2013-12-11 | — | — | EP | disclosed |
| WO-2012106569-A1 | ALPHA-KETOHETEROCYCLES AND METHODS OF MAKING AND USING | BOGER DALE L (US) | 2012-08-09 | — | — | WO | disclosed |
| WO-2012012320-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENIUM PHARMACEUTICALS, INC. (US) | 2012-01-26 | — | — | WO | disclosed |
| US-20120015942-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015942-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | HDAC6, HDAC1, HDAC2 | DRD2 2431/4885HTR1D 1916/4885DRD3 2545/4885 |
| US-20140243334-A1 | SUBSTITUTED HYDOXAMIC ACIDS AND USES THEREOF | HDAC6, H1-3, H1-5 | DRD2 1767/4885HTR1D 736/4885DRD3 1694/4885 |
| US-20130338196-A1 | ALPHA-KETOHETEROCYCLES AND METHODS OF MAKING AND USING | FAAH, FAAH2, CNR2 | DRD2 1400/4885HTR1D 536/4885DRD3 1300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.