Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pentaethylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SNCA | P37840 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29137364 | 1.00 | ALDH1A1 (0.49) | ALDH1A1CYP2C9CYP1A2SMN1; SMN2LMNA | |
| SCHEMBL29249377 | 1.00 | ALDH1A1 (0.49) | ALDH1A1CYP2C9CYP1A2SMN1; SMN2LMNA | |
| SCHEMBL28704841 | 1.00 | ALDH1A1 (0.49) | ALDH1A1CYP2C9CYP1A2SMN1; SMN2LMNA | |
| SCHEMBL28618062 | 1.00 | ALDH1A1 (0.49) | ALDH1A1CYP2C9CYP1A2SMN1; SMN2LMNA | |
| Hexaethylene Glycol SCHEMBL11280667 | 1.00 | ALDH1A1 (0.49) | ALDH1A1CYP2C9CYP1A2SMN1; SMN2LMNA | |
| Tetraethylene Glycol SCHEMBL1145155 | 1.00 | ALDH1A1 (0.49) | ALDH1A1CYP2C9CYP1A2SMN1; SMN2LMNA | |
| Hexaethylene Glycol SCHEMBL4379136 | 1.00 | ALDH1A1 (0.49) | ALDH1A1CYP2C9CYP1A2SMN1; SMN2LMNA | |
| Tetraethylene Glycol SCHEMBL3062384 | 1.00 | ALDH1A1 (0.49) | ALDH1A1CYP2C9CYP1A2SMN1; SMN2LMNA | |
| Triethylene Glycol SCHEMBL6130636 | 1.00 | ALDH1A1 (0.49) | ALDH1A1CYP2C9CYP1A2SMN1; SMN2LMNA | |
| SCHEMBL27633211 | 1.00 | ALDH1A1 (0.49) | ALDH1A1CYP2C9CYP1A2SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120136898-A | Molecular trefoil compound and synthesis method thereof | 华东师范大学 | 2025-06-13 | — | — | CN | claimed |
| CN-119285682-A | X-ray luminescent material and synthesis method and application thereof | 中国科学院福建物质结构研究所 | 2025-01-10 | — | — | CN | claimed |
| CN-116730973-B | 4-tert-butyl benzyloxy substituted calixarene crown ether compound as well as preparation method and application thereof | 兰州大学 | 2023-10-20 | — | — | CN | claimed |
| CN-116730973-A | 4-tert-butyl benzyloxy substituted calixarene crown ether compound as well as preparation method and application thereof | 兰州大学 | 2023-09-12 | — | — | CN | claimed |
| CN-111589420-A | Millimeter-grade macroporous-mesoporous carbon sphere/cup [4] -double crown-6 interpenetrating composite material and preparation method and application thereof | 东华理工大学 | 2020-08-28 | — | — | CN | claimed |
| CN-119285682-A | X-ray luminescent material and synthesis method and application thereof | 中国科学院福建物质结构研究所 | 2025-01-10 | — | — | CN | disclosed |
| CN-118290412-A | Glutamate dehydrogenase degradation agent and preparation method and application thereof | 杭州汉菁生物科技有限公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-116730973-B | 4-tert-butyl benzyloxy substituted calixarene crown ether compound as well as preparation method and application thereof | 兰州大学 | 2023-10-20 | — | — | CN | disclosed |
| CN-116730973-A | 4-tert-butyl benzyloxy substituted calixarene crown ether compound as well as preparation method and application thereof | 兰州大学 | 2023-09-12 | — | — | CN | disclosed |
| CN-112707900-B | Protein degrading agents and their use in the treatment of disease | 上海科技大学 | 2022-06-10 | — | — | CN | disclosed |
| WO-2021078301-A1 | PROTEIN DEGRADING AGENT AND USE THEREOF IN TREATMENT OF DISEASES | 上海科技大学 | 2021-04-29 | — | — | WO | disclosed |
| CN-112707900-A | Protein degradation agent and application thereof in disease treatment | 上海科技大学 | 2021-04-27 | — | — | CN | disclosed |
| US-6294697-B1 | COMPOUND COMPRISING REACTION PRODUCT OF AT LEAST ONE DISCRETE OXYETHYLENE-CONTAINING CROSSLINKING MOIETY HAVING AT LEAST TWO REACTIVE GROUPS, AND AT LEAST TWO LOW MOLECULAR WEIGHT OXYETHYLENE-CONTAINING MOIETIES COVALENTLY COUPLED THERETO | THE UNIVERSITY OF WASHINGTON | 2001-09-25 | — | — | US | disclosed |
| US-6117413-A | Radionuclide-binding compound, a radionuclide delivery system, a method of making a radium complexing compound, a method of extracting a radionuclide, and a method of delivering a radionuclide | BATTELLE MEMORIAL INSTITUTE (US) | 2000-09-12 | — | — | US | disclosed |
| WO-1999024081-A2 | A RADIONUCLIDE-BINDING COMPOUND AND ITS DELIVERY SYSTEM | BATTELLE MEMORIAL INSTITUTE (US) | 1999-05-20 | — | — | WO | disclosed |
| EP-0670840-B1 | BIS-CROWN CALIX[4]ARENES, METHOD FOR PREPARING SAME AND USE THEREOF FOR SELECTIVELY RECOVERING CESIUM AND ACTINIDES | COMMISSARIAT ENERGIE ATOMIQUE (FR) | 1997-01-22 | — | — | EP | disclosed |
| EP-0341409-B1 | Platinum (II) complexes, their preparation and use as antitumour agents | BOEHRINGER MANNHEIM ITALIA (IT) | 1993-12-29 | — | — | EP | disclosed |
| EP-0415939-A1 | PLATINUM(II) COMPLEXES, THEIR PREPARATION AND USE AS ANTI-TUMOUR AGENTS | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1991-03-13 | — | — | EP | disclosed |
| EP-0341409-A1 | Platinum (II) complexes, their preparation and use as antitumour agents | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1989-11-15 | — | — | EP | disclosed |
| WO-1989009218-A1 | PLATINUM(II) COMPLEXES, THEIR PREPARATION AND USE AS ANTI-TUMOUR AGENTS | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1989-10-05 | — | — | WO | disclosed |