Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CETP | P11597 | 6/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | FABP1 | P07148 | 1/20 | 0.39 |
| ▸ | FABP6 | P51161 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18881235 | 0.86 | ALDH1A1 (0.44) | SMN1; SMN2L3MBTL1CHRM2CETPPOLB | |
| SCHEMBL8664925 | 0.85 | TRPA1 (0.46) | SMN1; SMN2L3MBTL1SLC6A2TAAR1CHRM2 | |
| SCHEMBL18881321 | 0.83 | NPC1 (0.41) | SMN1; SMN2L3MBTL1CHRM2TRPA1POLB | |
| SCHEMBL25377877 | 0.83 | SLC6A2 (0.53) | SMN1; SMN2L3MBTL1SLC6A2TAAR1CHRM2 | |
| SCHEMBL3466660 | 0.82 | KDM4E (0.45) | SMN1; SMN2L3MBTL1TAAR1CYP2D6CETP | |
| SCHEMBL23190647 | 0.82 | CETP (0.44) | SMN1; SMN2L3MBTL1CHRM2LMNACETP | |
| SCHEMBL19115605 | 0.81 | SMN1; SMN2 (0.39) | SMN1; SMN2L3MBTL1CHRM2LMNACYP2D6 | |
| SCHEMBL19916541 | 0.81 | FDPS (0.46) | SMN1; SMN2L3MBTL1TAAR1CHRM2LMNA | |
| SCHEMBL21370891 | 0.79 | L3MBTL1 (0.37) | SMN1; SMN2L3MBTL1TAAR1CHRM2CETP | |
| SCHEMBL4728011 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2L3MBTL1CHRM2LMNACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391606-A1 | ETHANAMINE COMPOUNDS AND THEIR USE FOR TREATING DEPRESSION | AstraZeneca AB (SE) | 2011-12-07 | — | — | EP | claimed |
| WO-2010074647-A1 | ETHANAMINE COMPOUNDS AND THEIR USE FOR TREATING DEPRESSION | ASTRAZENECA AB (SE) | 2010-07-01 | — | — | WO | claimed |
| EP-2391606-A1 | ETHANAMINE COMPOUNDS AND THEIR USE FOR TREATING DEPRESSION | AstraZeneca AB (SE) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010074647-A1 | ETHANAMINE COMPOUNDS AND THEIR USE FOR TREATING DEPRESSION | ASTRAZENECA AB (SE) | 2010-07-01 | — | — | WO | disclosed |