Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL535731 | 0.83 | L3MBTL1 (0.55) | L3MBTL1ALDH1A1NFE2L2KDM4EPOLB | |
| SCHEMBL16239167 | 0.80 | L3MBTL1 (0.37) | METAP1L3MBTL1ALDH1A1LMNANFE2L2 | |
| SCHEMBL2148128 | 0.80 | L3MBTL1 (0.37) | L3MBTL1ALDH1A1NFE2L2KDM4EMAPT | |
| SCHEMBL13379447 | 0.80 | MAPK1 (0.39) | L3MBTL1ALDH1A1NFE2L2KDM4EMAPT | |
| SCHEMBL21358044 | 0.78 | KDM4E (0.39) | METAP1L3MBTL1ALDH1A1LMNAKDM4E | |
| SCHEMBL5376069 | 0.78 | TLR7 (0.45) | METAP1L3MBTL1ALDH1A1LMNAKDM4E | |
| SCHEMBL30441012 | 0.78 | KDM4E (0.46) | METAP1L3MBTL1ALDH1A1LMNAKDM4E | |
| SCHEMBL28085307 | 0.78 | L3MBTL1 (0.41) | METAP1L3MBTL1ALDH1A1LMNAKDM4E | |
| SCHEMBL31628026 | 0.77 | ALDH1A1 (0.41) | L3MBTL1ALDH1A1NFE2L2KDM4EMAPT | |
| SCHEMBL23971148 | 0.76 | ALDH1A1 (0.37) | ALDH1A1LMNAGABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115551862-B | Macrocyclic inhibitors of peptidyl arginine deiminase | 吉利德科学公司 | 2024-04-12 | — | — | CN | disclosed |
| EP-2265600-A1 | PYRIDINYL AMIDES FOR THE TREATMENT OF CNS AND METABOLIC DISORDERS | Pfizer Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009098576-A1 | PYRIDINYL AMIDES FOR THE TREATMENT OF CNS AND METABOLIC DISORDERS | PFIZER INC. (US) | 2009-08-13 | — | — | WO | disclosed |