Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 9/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.43 |
| ▸ | PRF1 | P14222 | 1/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | COMT | P21964 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3467162 | 0.82 | KIF11 (0.65) | NOTUMCYP1A2KIF11PDE3BPDE3A | |
| SCHEMBL3312695 | 0.79 | KIF11 (0.68) | NOTUMCYP1A2KIF11PDE3BPDE3A | |
| SCHEMBL3467329 | 0.75 | KIF11 (0.46) | NOTUMKIF11PDE3BPDE3AGRIA1 | |
| SCHEMBL3466905 | 0.72 | OTUD7B (0.52) | KIF11GRIA1CACNG8ABL1 | |
| SCHEMBL3467035 | 0.72 | NOTUM (0.43) | NOTUMCYP1A2PDE3BPDE3APRF1 | |
| SCHEMBL2698021 | 0.72 | NOTUM (0.61) | NOTUMCYP1A2PDE3BPDE3ACOMT | |
| SCHEMBL4890959 | 0.68 | KIF11 (0.68) | CYP1A2KIF11PDE3BPDE3AGRIA1 | |
| SCHEMBL1899619 | 0.65 | PDE3B (0.56) | CYP1A2KIF11PDE3BPDE3AGRIA1 | |
| SCHEMBL700817 | 0.65 | NOTUM (0.51) | NOTUMCYP1A2PDE3BPDE3AAR | |
| SCHEMBL18189320 | 0.64 | KIF11 (0.58) | CYP1A2KIF11PDE3BPDE3AGRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010074807-A1 | 3, 4-DIHYDROQUINOLIN-2 ( 1H ) -ONE DERIVATIVES AS SODIUM CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2010-07-01 | — | — | WO | disclosed |