Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 8/20 | 0.65 |
| ▸ | TDP2 | O95551 | 2/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3467329 | 0.83 | KIF11 (0.46) | KIF11PDE3BPDE3AHRH3NOTUM | |
| SCHEMBL3466639 | 0.82 | NOTUM (0.45) | KIF11TDP2PDE3BPDE3AKDR | |
| SCHEMBL1903306 | 0.80 | KIF11 (0.80) | KIF11TDP2PDE3BPDE3ACDK2 | |
| SCHEMBL1396616 | 0.79 | KIF11 (1.00) | KIF11TDP2PDE3BPDE3AAKT1 | |
| SCHEMBL3466905 | 0.78 | OTUD7B (0.52) | KIF11HRH3CYP11B1CYP11B2 | |
| SCHEMBL4596437 | 0.77 | KIF11 (0.65) | KIF11TDP2PDE3BPDE3ACHRNB2 | |
| SCHEMBL4888861 | 0.75 | KIF11 (0.86) | KIF11TDP2PDE3BPDE3AAKT1 | |
| SCHEMBL4596312 | 0.75 | KIF11 (0.63) | KIF11TDP2PDE3BPDE3ACHRNB2 | |
| SCHEMBL4888035 | 0.75 | KIF11 (0.86) | KIF11TDP2PDE3BPDE3AAKT1 | |
| SCHEMBL4898372 | 0.75 | KIF11 (0.72) | KIF11TDP2PDE3BPDE3ACHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010074807-A1 | 3, 4-DIHYDROQUINOLIN-2 ( 1H ) -ONE DERIVATIVES AS SODIUM CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2010-07-01 | — | — | WO | disclosed |