Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 7/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3465068 | 0.84 | THRB (0.38) | THRBL3MBTL1POLBTSHRALDH1A1 | |
| SCHEMBL2821656 | 0.83 | TBXAS1 (0.36) | THRBL3MBTL1POLBTSHRALDH1A1 | |
| SCHEMBL2820072 | 0.79 | ALDH1A1 (0.35) | THRBL3MBTL1POLBTSHRALDH1A1 | |
| SCHEMBL2821658 | 0.79 | MAPT (0.42) | THRBL3MBTL1POLBALDH1A1HPGD | |
| SCHEMBL2822454 | 0.75 | PPARA (0.40) | THRBL3MBTL1POLBTSHRALDH1A1 | |
| SCHEMBL2821913 | 0.71 | ALDH1A1 (0.37) | POLBALDH1A1HPGDKDM4EKMT2A | |
| SCHEMBL2820153 | 0.71 | ALDH1A1 (0.37) | POLBALDH1A1HPGDKDM4EKMT2A | |
| SCHEMBL2820147 | 0.71 | ALDH1A1 (0.37) | POLBALDH1A1HPGDKDM4EKMT2A | |
| SCHEMBL2819988 | 0.70 | SMN1; SMN2 (0.41) | THRBL3MBTL1POLBTSHRALDH1A1 | |
| SCHEMBL12240333 | 0.69 | HPGD (0.49) | L3MBTL1ALDH1A1HPGDKMT2ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010071813-A1 | AGONISTS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR-α | ARYX THERAPEUTICS, INC. (US) | 2010-06-24 | — | — | WO | claimed |
| WO-2010071813-A1 | AGONISTS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR-α | ARYX THERAPEUTICS, INC. (US) | 2010-06-24 | — | — | WO | disclosed |