Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | CHKA | P35790 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3468115 | 0.88 | KIF11 (0.47) | KIF11AKT1CDK2CDK1KIT | |
| SCHEMBL3467348 | 0.81 | KIF11 (0.41) | KIF11FFAR1MAPT | |
| SCHEMBL4891219 | 0.78 | KIF11 (0.56) | KIF11AKT1CDK2CDK1KIT | |
| SCHEMBL3468263 | 0.78 | KIF11 (0.53) | KIF11AKT1CDK2CDK1KIT | |
| SCHEMBL3308412 | 0.78 | KIF11 (0.53) | KIF11AKT1CDK2CDK1KIT | |
| SCHEMBL3467771 | 0.77 | KIF11 (0.48) | KIF11CRBNAKT1CDK2CDK1 | |
| SCHEMBL3467592 | 0.77 | KIF11 (0.52) | KIF11AKT1CDK2CDK1KIT | |
| SCHEMBL3467252 | 0.73 | KIF11 (0.53) | KIF11AKT1CDK2CDK1KIT | |
| SCHEMBL4596144 | 0.72 | KIF11 (0.60) | KIF11AKT1CDK2CDK1KIT | |
| SCHEMBL4596470 | 0.72 | KIF11 (0.49) | KIF11CRHBPCRHR2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010074807-A1 | 3, 4-DIHYDROQUINOLIN-2 ( 1H ) -ONE DERIVATIVES AS SODIUM CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2010-07-01 | — | — | WO | disclosed |