Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.67 |
| ▸ | PDE6A | P16499 | 1/20 | 0.67 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.67 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | STK4 | Q13043 | 1/20 | 0.49 |
| ▸ | STK3 | Q13188 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3469600 | 0.82 | PDE5A (0.46) | PDE5APDE6APDE1BPDE3ACYP1A2 | |
| SCHEMBL3469240 | 0.80 | PDE5A (1.00) | PDE5APDE6APDE1BPDE3ASLC6A3 | |
| SCHEMBL3467938 | 0.78 | PDE5A (0.67) | PDE5APDE6APDE1BPDE3ASLC6A3 | |
| SCHEMBL3467028 | 0.75 | PDE5A (0.60) | PDE5APDE6APDE1BPDE3ASLC6A3 | |
| SCHEMBL5404986 | 0.74 | FLT3 (0.52) | LRRK2CYP1A2CYP3A4MAPK1CYP2D6 | |
| SCHEMBL5404980 | 0.73 | MAPT (0.41) | PDE5APDE6APDE1BPDE3ACYP1A2 | |
| SCHEMBL3467020 | 0.73 | PDE5A (0.60) | PDE5APDE6APDE1BPDE3ASLC6A3 | |
| SCHEMBL6937711 | 0.73 | PDE5A (0.56) | PDE5APDE6APDE1BPDE3ASLC6A3 | |
| SCHEMBL14349473 | 0.72 | TRPM8 (0.56) | PDE5APDE6APDE1BPDE3ASTK4 | |
| SCHEMBL30455146 | 0.72 | TRPM8 (0.56) | PDE5APDE6APDE1BPDE3ASTK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | claimed |
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | disclosed |