Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | MAP4K3 | Q8IVH8 | 4/20 | 0.39 |
| ▸ | MET | P08581 | 4/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | GRK5 | P34947 | 2/20 | 0.36 |
| ▸ | GRK2 | P25098 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.34 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3788088 | 0.85 | LRRK2 (0.40) | LRRK2MAP4K3METGRK5GRK2 | |
| Hydrochloric Acid SCHEMBL3783991 | 0.81 | LRRK2 (0.38) | LRRK2MAP4K3METFLT3GRK5 | |
| Hydrochloric Acid SCHEMBL3788144 | 0.81 | KDM4E (0.41) | LRRK2METGRK5KCNH2SLC6A2 | |
| Hydrochloric Acid SCHEMBL3786764 | 0.80 | LRRK2 (0.40) | LRRK2METGRK5GRK2MKNK1 | |
| Hydrochloric Acid SCHEMBL3786770 | 0.79 | ILK (0.50) | METKCNH2 | |
| Hydrochloric Acid SCHEMBL3782265 | 0.79 | LRRK2 (0.40) | LRRK2MAP4K3METGRK5GRK2 | |
| SCHEMBL3792500 | 0.79 | CASP3 (0.39) | LRRK2MAP4K3METGRK5GRK2 | |
| SCHEMBL3789068 | 0.79 | L3MBTL1 (0.39) | LRRK2MAP4K3METGRK5GRK2 | |
| Hydrochloric Acid SCHEMBL3790869 | 0.79 | LRRK2 (0.39) | LRRK2MAP4K3METFLT3GRK5 | |
| Hydrochloric Acid SCHEMBL3793473 | 0.79 | ALK (0.38) | LRRK2MAP4K3METMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215085-A2 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009053737-A2 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2009-04-30 | — | — | WO | disclosed |