Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 6/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3469572 | 1.00 | AKR1C3 (0.47) | AKR1C3TBXAS1TRPV4TRPV1MRGPRX4 | |
| SCHEMBL3113886 | 0.82 | TBXAS1 (0.47) | AKR1C3TBXAS1TRPV4TRPV1MRGPRX4 | |
| SCHEMBL3113876 | 0.82 | TBXAS1 (0.47) | AKR1C3TBXAS1TRPV4TRPV1MRGPRX4 | |
| SCHEMBL25577239 | 0.81 | MEN1 (0.43) | TRPV4 | |
| SCHEMBL30469174 | 0.81 | MEN1 (0.43) | TRPV4 | |
| SCHEMBL21470185 | 0.79 | ALDH1A1 (0.44) | TRPV4TRPV1MRGPRX4DGAT1 | |
| SCHEMBL27944353 | 0.79 | AKR1C3 (0.47) | AKR1C3TBXAS1RXRARXRBRXRG | |
| SCHEMBL3773279 | 0.79 | P2RX7 (0.39) | AKR1C3TRPV4TRPV1MRGPRX4HDAC4 | |
| SCHEMBL3789100 | 0.78 | MRGPRX4 (0.41) | AKR1C3TRPV4TRPV1MRGPRX4HDAC4 | |
| SCHEMBL25212522 | 0.77 | AKR1C3 (0.46) | AKR1C3TBXAS1HDAC4RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023097234-A1 | SPIROCYCLIC MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION | GENENTECH, INC. (US) | 2023-06-01 | — | — | WO | disclosed |
| EP-2253615-A1 | Cyclopropyl amide derivatives | AstraZeneca AB (SE) | 2010-11-24 | — | — | EP | disclosed |