Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | BCR | P11274 | 2/20 | 0.51 |
| ▸ | SMO | Q99835 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.40 |
| ▸ | MAPKAPK5 | Q8IW41 | 3/20 | 0.40 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.39 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | EED | O75530 | 1/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3468104 | 0.84 | FGFR2 (0.42) | SYKFGFR2FLT3PTK6MAPKAPK5 | |
| SCHEMBL11939102 | 0.81 | TTK (0.45) | ABL1BCRSYKPTK6MAPKAPK5 | |
| SCHEMBL3470478 | 0.80 | MAPKAPK5 (0.43) | SYKFGFR2FLT3PTK6MAPKAPK5 | |
| SCHEMBL3467726 | 0.80 | TTK (0.57) | ABL1BCRMAPKAPK5AURKAAURKB | |
| SCHEMBL3466346 | 0.79 | TTK (0.45) | SYKTTKEGFR | |
| SCHEMBL1674087 | 0.79 | MAPKAPK5 (0.60) | SYKFGFR2FLT3PTK6MAPKAPK5 | |
| SCHEMBL8241606 | 0.79 | AURKA (0.58) | SYKFGFR2FLT3PTK6MAPKAPK5 | |
| SCHEMBL14537044 | 0.79 | AURKA (0.45) | SYKFGFR2FLT3PTK6MAPKAPK5 | |
| SCHEMBL11939505 | 0.78 | FLT1 (0.47) | SYKFGFR2FLT3MAPKAPK5CACNA2D1 | |
| SCHEMBL2401175 | 0.77 | MAPKAPK5 (0.60) | SYKFGFR2FLT3MAPKAPK5TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | claimed |
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | disclosed |